1304141-55-6Relevant articles and documents
An enantioselective approach to 2,3-disubstituted indolines through consecutive Bronsted acid/Pd-complex-promoted tandem reactions
Duan, Ying,Chen, Mu-Wang,Ye, Zhi-Shi,Wang, Duo-Sheng,Chen, Qing-An,Zhou, Yong-Gui
supporting information; experimental part, p. 7193 - 7197 (2011/07/30)
In tandem: A divergent and enantioselective approach to 2,3-disubstituted indolines was developed through consecutive Bronsted acid/Pd-complex- promoted tandem reactions from simple 2-substituted indoles and aldehydes in one operation to give up to 98 % ee (see scheme; R1=H, F, or Me; R 2=alkyl; R3=aryl or alkyl). Three Bronsted acid promoted steps and two Pd-catalyzed hydrogenation steps were involved in this process. Copyright
