130663-39-7 Usage
Description
PD 123,319 DITRIFLUOROACETATE, also known as PD 123,319, is a selective non-peptide angiotensin AT2 receptor antagonist. It is an imidazopyridine consisting of 4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine with 4-(dimethylamino)-3-methylbenzyl, diphenylacetyl, and carboxy groups at positions 1, 5, and 6, respectively.
Uses
Used in Pharmaceutical Industry:
PD 123,319 DITRIFLUOROACETATE is used as a selective non-peptide angiotensin AT2 receptor antagonist for the treatment and management of various cardiovascular and renal diseases. It helps in modulating the renin-angiotensin system, which plays a crucial role in regulating blood pressure and fluid balance in the body.
Used in Research Applications:
PD 123,319 DITRIFLUOROACETATE is used as a research tool in the field of pharmacology and molecular biology. It is employed to study the role of angiotensin AT2 receptors in various physiological and pathological processes, including cell growth, differentiation, and apoptosis. This helps researchers understand the underlying mechanisms of diseases and develop targeted therapies.
Used in Drug Development:
PD 123,319 DITRIFLUOROACETATE is used as a lead compound in the development of new drugs targeting angiotensin AT2 receptors. Its selective antagonistic properties make it a valuable starting point for designing and synthesizing novel compounds with improved pharmacological profiles and therapeutic applications.
Biological Activity
Potent, selective, non-peptide angiotensin AT 2 receptor antagonist. IC 50 values are 34 and 210 nM in rat adrenal tissue and brain respectively.
references
[1] blankley c j, hodges j c, klutchko s r, et al. synthesis and structure-activity relationships of a novel series of non-peptide angiotensin ii receptor binding inhibitors specific for the at2 subtype. journal of medicinal chemistry, 1991, 34(11): 3248-3260.[2] boulay g, servant g, luong t t, et al. modulation of angiotensin ii binding affinity by allosteric interaction of polyvinyl sulfate with an intracellular domain of the dup-753-sensitive angiotensin ii receptor of bovine adrenal glomerulosa. molecular pharmacology, 1992, 41(4): 809-815.[3] siragy h. angiotensin ii receptor blockers: review of the binding characteristics. the american journal of cardiology, 1999, 84(10): 3-8.
Check Digit Verification of cas no
The CAS Registry Mumber 130663-39-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,0,6,6 and 3 respectively; the second part has 2 digits, 3 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 130663-39:
(8*1)+(7*3)+(6*0)+(5*6)+(4*6)+(3*3)+(2*3)+(1*9)=107
107 % 10 = 7
So 130663-39-7 is a valid CAS Registry Number.
InChI:InChI=1/C31H32N4O3.2C2HF3O2/c1-21-16-22(14-15-26(21)33(2)3)18-34-20-32-25-19-35(28(31(37)38)17-27(25)34)30(36)29(23-10-6-4-7-11-23)24-12-8-5-9-13-24;2*3-2(4,5)1(6)7/h4-16,20,28-29H,17-19H2,1-3H3,(H,37,38);2*(H,6,7)/t28-;;/m0../s1
