131029-02-2

Basic information

• Product Name: (S)-1-(4-methoxyphenyl)propan-2-yl acetate
• Synonyms: (S)-1-(4-methoxyphenyl)propan-2-yl acetate
• CAS NO: 131029-02-2
• Molecular Weight: 208.257
• Mol File: 131029-02-2.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: (S)-1-(4-methoxyphenyl)propan-2-yl acetate(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-1-(4-methoxyphenyl)propan-2-yl acetate(131029-02-2)
• EPA Substance Registry System: (S)-1-(4-methoxyphenyl)propan-2-yl acetate(131029-02-2)

Safety Data

• Hazardous Substances Data: 131029-02-2(Hazardous Substances Data)

Upstream product

• 187737-37-7 propene 
• 1600-27-7 mercury(II) diacetate 
• 100-66-3 methoxybenzene 
• 86119-84-8 phosphoric acid 
• 64-19-7 acetic acid 
• 108-24-7 acetic anhydride 
• 104-46-1 anethole 
• 131029-01-1 (S)-(+)-1-(4-methoxyphenyl)propan-2-ol 
• 123-11-5 4-methoxy-benzaldehyde 
• 111004-04-7 (1R,2S)-1-(4'-methoxyphenyl)-1,2-propanediol 
• 122-84-9 4-methoxybenzyl methyl ketone 

Downstream Products

• 937018-21-8 (S)-1-(3-(chlorosulfonyl)-4-methoxyphenyl)propan-2-yl acetate 
• 112101-81-2 5-((R)-2-amino-1-propyl)-2-methoxybenzenesulphonamide 
• 106133-20-4 (R)-tamsulosin 
• 937018-23-0 (S)-1-(4-methoxy-3-sulfamoylphenyl)propan-2-yl acetate 
• 937018-25-2 (R)-5-(2-azidopropyl)-2-methoxybenzenesulfonamide 
• 937018-24-1 (S)-5-(2-hydroxypropyl)-2-methoxybenzenesulfonamide 

Relevant articles and documents

Broad Scope Synthesis of Ester Precursors of Nonfunctionalized Chiral Alcohols Based on the Asymmetric Hydrogenation of α,β-Dialkyl-, α,β-Diaryl-, and α-Alkyl-β-aryl-vinyl Esters

The catalytic asymmetric hydrogenation of trisubstituted enol esters using Rh catalysts bearing chiral phosphine-phosphite ligands (P-OP) has been studied. Substrates covered comprise α,β-dialkyl, α-alkyl-β-aryl, and α,β-diarylvinyl esters, the corresponding hydrogenation products being suitable precursors to prepare synthetically relevant chiral nonfunctionalized alcohols. A comparison of reactivity indicates that it decreases in the order: α,β-dialkyl > α-alkyl-β-aryl > α,β-diaryl. Based on the highly modular structure of P-OP ligands employed, catalyst screening identified highly enantioselective catalysts for α,β-dialkyl (95-99% ee) and nearly all of α-alkyl-β-aryl substrates (92-98% ee), with the exception of α-cyclohexyl-β-phenylvinyl acetate which exhibited a low enantioselectivity (47% ee). Finally, α,β-diarylvinyl substrates showed somewhat lower enantioselectivities (79-92% ee). In addition, some of the catalysts provided a high enantioselectivity in the hydrogenation of E/Z mixtures (ca. Z/E = 75:25) of α,β-dialkylvinyl substrates, while a dramatic decrease on enantioselectivity was observed in the case of α-methyl-β-anisylvinyl acetate (Z/E = 58:42). Complementary deuteration reactions are in accord with a highly enantioselective hydrogenation for both olefin isomers in the case of α,β-dialkylvinyl esters. In contrast, deuteration shows a complex behavior for α-methyl-β-anisylvinyl acetate derived from the participation of the E isomer in the reaction.

DIRECT ANTI-MARKOVNIKOV ADDITION OF ACIDS TO ALKENES

A method of making an anti-Markovnikov addition product is carried out by reacting an acid with an alkene or alkyne in a dual catalyst reaction system to the exclusion of oxygen to produce said anti-Markovnikov addition product; the dual catalyst reaction system comprising a single electron oxidation catalyst in combination with a hydrogen atom donor catalyst. Compositions useful for carrying out such methods are also described.

A new enzymatic approach to (R)-Tamsulosin hydrochloride

An enantioselective baker's yeast mediated approach to the pharmacologically active (R)-enantiomer of Tamsulosin hydrochloride is reported.