1312815-03-4Relevant articles and documents
Novel ATP competitive MK2 inhibitors with potent biochemical and cell-based activity throughout the series
Oubrie, Arthur,Kaptein, Allard,De Zwart, Edwin,Hoogenboom, Niels,Goorden, Rianne,Van De Kar, Bas,Van Hoek, Maaike,De Kimpe, Vera,Van Der Heijden, Ruud,Borsboom, Judith,Kazemier, Bert,De Roos, Jeroen,Scheffers, Michiel,Lommerse, Jos,Schultz-Fademrecht, Carsten,Barf, Tjeerd
, p. 613 - 618 (2012/03/11)
Optimization of our previously described pyrrolopiperidone series led to the identification of a new benzamide sub-series, which exhibits consistently high potency in biochemical and cell-based assays throughout the series. Strong inhibition of LPS-induce