1316815-11-8Relevant articles and documents
Synthesis of [2H5]-ebastine fumarate and [ 2H5]-hydroxyebastine
Yu, Zhoujie,Wang, Wei,Chen, Liqin
, p. 352 - 356 (2012/06/01)
This study describes the synthesis of deuterium-labelled ebastine fumarate and its deuterium-labelled metabolite hydroxyebastine. The synthesis of the two desired compounds both used [2H5]-bromodiphenylmethane as deuterium-labelled reagent, which was synthesized beforehand in three steps. [2H5]-ebastine was synthesized in further three steps with a 27% overall yield and [2H5]-hydroxyebastine was synthesized in further seven steps with a 13% overall yield.