13185-18-7

Basic information

• Product Name: 8-METHOXY-3,4-DIHYDRONAPHTHALEN-1(2H)-ONE
• Synonyms: 8-METHOXY-3,4-DIHYDRONAPHTHALEN-1(2H)-ONE;8-Methoxy-α-Tetralone;8-METHOXY-A-TETRALONE;8-METHOXY-1-TETRALONE;3,4-Dihydro-8-methoxy-1(2H)-naphthalenone;8-Methoxy-3,4-dihydronaphthalen-1-one;1(2H)-Naphthalenone, 3,4-dihydro-8-Methoxy-;8-Methoxy-1,2,3,4-tetrahydronaphthalen-1-one
• CAS NO: 13185-18-7
• Molecular Formula: C₁₁H₁₂O₂
• Molecular Weight: 176.21
• Mol File: 13185-18-7.mol
• Article Data: 16

Chemical Properties

• Melting Point: 128-130℃
• Boiling Point: 325℃
• Flash Point: 155℃
• Appearance: /
• Density: 1.124
• Vapor Pressure: 0.000239mmHg at 25°C
• Refractive Index: 1.548
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 8-METHOXY-3,4-DIHYDRONAPHTHALEN-1(2H)-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 8-METHOXY-3,4-DIHYDRONAPHTHALEN-1(2H)-ONE(13185-18-7)
• EPA Substance Registry System: 8-METHOXY-3,4-DIHYDRONAPHTHALEN-1(2H)-ONE(13185-18-7)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 13185-18-7(Hazardous Substances Data)

Usage

General Description

8-Methoxy-3,4-dihydronaphthalen-1(2H)-one, also known as methoxydihydronaphthalenone, is a chemical compound with the molecular formula C12H14O2. It is a white crystalline substance with a mild, sweet odor. The compound is commonly utilized in the fragrance industry as a fixative and fragrance ingredient. It is known for its long-lasting and stable scent, making it a popular choice for perfumes, colognes, and other scented products. Additionally, it is also used in the synthesis of pharmaceuticals and other organic compounds. Overall, 8-Methoxy-3,4-dihydronaphthalen-1(2H)-one plays a significant role in the fragrance and chemical industries and is valued for its aromatic and stabilizing properties.

InChI:InChI=1/C11H12O2/c1-13-10-7-3-5-8-4-2-6-9(12)11(8)10/h3,5,7H,2,4,6H2,1H3

Upstream product

• 569-42-6 1,8-dihydroxynaphthalene 
• 57816-04-3 methyl 4-(3-methoxyphenyl)butanoate 
• 137744-81-1 (E)-4-(m-methoxyphenyl)but-3-enoic acid 
• 766-85-8 3-methoxy-1-iodobenzene 
• 1292823-28-9 4-(toluene-p-sulfonoxy)-8-methoxy-1-tetralone 
• 6520-83-8 ethyl 2-methoxy-6-methylbenzoate 
• 292638-85-8 acrylic acid methyl ester 
• 77260-10-7 C₁₂H₁₄BrN₃O₂ 
• 77259-95-1 γ-(2-bromo-5-methoxyphenyl)butyric acid 
• 24743-11-1 4-(m-methoxyphenyl)butanoic acid 
• 824-98-6 m-methoxybenzyl chloride 
• 57816-01-0 ethyl 4-(3'-methoxyphenyl)butyrate 
• 7695-47-8 8-hydroxy-1,2,3,4-tetrahydro-1-naphthalenone 
• 74-88-4 methyl iodide 

Downstream Products

• 535935-61-6 8-methoxy-1,2,3,4-tetrahydro-1-naphthalenamine 
• 117661-46-8 9-methoxy-2-nitro-naphto<1,2-b>furan 
• 77260-14-1 N-(2,4-Dinitro-phenyl)-N'-[8-methoxy-3,4-dihydro-2H-naphthalen-(1E)-ylidene]-hydrazine 
• 5656-61-1 4,5-dihydro-3H-naphtho<1,8-bc>furan 
• 133601-13-5 8-hydroxymethyl-1,2,3,4-tetrahydro-1-naphthalenone 
• 77260-16-3 N-[8-Bromo-5-methoxy-4a-methyl-4,4a,9,10-tetrahydro-3H-phenanthren-(2E)-ylidene]-N'-(2,4-dinitro-phenyl)-hydrazine 

Relevant articles and documents

A class of 2, 3 - dihydro - 1H - indenyl -4 - sulfonamide ROR γ regulator and its use (by machine translation)

The invention relates to a structure of formula (I) compound of formula or a stereoisomer thereof, tautomers or its pharmaceutically acceptable salt or solvate or prodrug, its preparation method, a pharmaceutical composition containing these modulators and their use in the treatment ROR γ-mediated inflammatory, metabolic and autoimmune disorders. (by machine translation)

An Expeditious Synthesis of 8-Methoxy-1-tetralone

8-Methoxy-1-tetralone was synthesized in a concise and efficient manner involving a sequential palladium-mediated cross-coupling reaction (Heck), catalytic hydrogenation, and intramolecular acylation mediated by Eaton's reagent or Lewis acids. The pivotal step in the synthesis was the use of a bromine substituent at the benzenoid C4 position of the intermediate methyl 4-arylbutyric ester to ensure cyclization ortho to the methoxy moiety and obviate cyclization at the para position to the thermodynamically preferred 6-methoxy-1-tetralone, the sole product obtained in the absence of this blocking group.