132139-15-2

Basic information

• Product Name: (S)-N,N-diphenyl-2-pyrrolidinecarboxamide
• Synonyms: (S)-N,N-diphenyl-2-pyrrolidinecarboxamide
• CAS NO: 132139-15-2
• Molecular Weight: 266.343
• Mol File: 132139-15-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (S)-N,N-diphenyl-2-pyrrolidinecarboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-N,N-diphenyl-2-pyrrolidinecarboxamide(132139-15-2)
• EPA Substance Registry System: (S)-N,N-diphenyl-2-pyrrolidinecarboxamide(132139-15-2)

Safety Data

• Hazardous Substances Data: 132139-15-2(Hazardous Substances Data)

Upstream product

• 1148-11-4 N-Benzyloxycarbonyl-L-proline 
• 61350-60-5 (S)-benzyloxycarbonyl-proline acid chloride 
• 62-53-3 aniline 
• 220510-58-7 tert-butyl (S)-2-(phenylcarbamoyl)pyrrolidine-1-carboxylate 
• 15761-39-4 1-(tert-butoxycarbonyl)-L-proline 
• 319-61-9 (S)-1-(trifluoroacetyl)pyrrolidine-2-carboxylic acid 
• 36724-68-2 (S)-N-trifluoroacetylproline acid chloride 
• 223769-31-1 (S)-1-(2,2,2-Trifluoro-acetyl)-pyrrolidine-2-carboxylic acid diphenylamide 

Downstream Products

• 223769-30-0 (S)-N,N-diphenyl-2-pyrrolidinemethanamine 

Relevant articles and documents

CYCLIZED ACETAMIDO DERIVATIVES AS DNA POLYMERASE THETA INHIBITORS

Provided and set forth herein are certain cyclized acetamido derivatives that are DNA Polymerase Theta (Ροlθ) inhibitors of Formula (I) and Formula (II). Also, provided are pharmaceutical compositions comprising such compounds, and methods of treating diseases treatable by inhibition of Polθ such as cancer, including homologous recombination (HR) deficient cancers, using such compounds and pharmaceutical compositions.

Enantioselective synthesis of binaphthol derivatives by oxidative coupling of naphthol derivatives catalyzed by chiral diamine-copper complexes

A highly efficient process of aerobic oxidative coupling of 2-naphthol derivatives catalyzed by 1 mol % of Cu(OH)Cl·TMEDA has been developed. Enantioselective oxidative coupling of naphthols was achieved by the use of 10 mol % of chiral catalysts prepared from proline-derived diamines and cuprous chloride, affording the corresponding binaphthols in good enantioselectivities of up to 78% ee. The ester moiety at the 3-position of the substrate was found to be essential for the good asymmetric induction observed in the present coupling reaction.