36724-68-2 Usage
Description
(S)-(-)-N-(TRIFLUOROACETYL)PROLYL CHLORIDE, also known as (S)-(?)-N-(Trifluoroacetyl)pyrrolidine-2-carbonyl chloride, is a chiral reagent used in the field of analytical chemistry. It is characterized by its ability to selectively react with specific enantiomers, making it a valuable tool for the separation and analysis of chiral compounds.
Uses
Used in Pharmaceutical Industry:
(S)-(-)-N-(TRIFLUOROACETYL)PROLYL CHLORIDE is used as a chiral derivatization reagent for the chiral separation of psychoactive, cathinoneand amphetamine-related drugs. This application is crucial in the development and quality control of medications, as well as in the detection and analysis of these drugs in various contexts.
Used in Forensic Science:
In the forensic science industry, (S)-(-)-N-(TRIFLUOROACETYL)PROLYL CHLORIDE is used as a chiral derivatization reagent for the estimation of cathinone-related drug enantiomers in biological samples like urine and plasma using GC-MS technique. This helps in the identification and quantification of these drugs in cases related to substance abuse or criminal investigations.
Used in Research and Development:
(S)-(-)-N-(TRIFLUOROACETYL)PROLYL CHLORIDE is also utilized in research and development for the study of chiral compounds and their interactions. This reagent aids in understanding the stereochemistry of various molecules, which is essential for the development of new drugs and the improvement of existing ones.
Check Digit Verification of cas no
The CAS Registry Mumber 36724-68-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,6,7,2 and 4 respectively; the second part has 2 digits, 6 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 36724-68:
(7*3)+(6*6)+(5*7)+(4*2)+(3*4)+(2*6)+(1*8)=132
132 % 10 = 2
So 36724-68-2 is a valid CAS Registry Number.
InChI:InChI=1/C7H7ClF3NO2/c8-5(13)4-2-1-3-12(4)6(14)7(9,10)11/h4H,1-3H2/t4-/m0/s1
36724-68-2Relevant articles and documents
A Short Synthesis of (S)-(+)-Tylophorine
Nordlander, J. Eric,Njoroge, F. George
, p. 1627 - 1630 (1987)
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A parallel preparation of a bicyclic N-chiral amine library and its use for chiral catalyst screening
Uozumi, Yasuhiro,Mizutani, Kanako,Nagai, Shin-ichi
, p. 407 - 410 (2007/10/03)
A parallel library of optically active bicyclic tertiary amines bearing N-chiral bridgehead nitrogen atoms was readily prepared by condensation of primary amines, cyclic amino acids and aldehydes. The enantiocontrolling ability of each of the library members was examined for the asymmetric alkylation of benzaldehyde with diethylzinc, and (3R,6R,7aS)-(2,3-diphenyl-6-hydroxy)hexahydro-1H-pyrrolo[1,2-c]imidazol-1- one, which contains a β-amino alcohol unit, showed high enantioselectivity.
Conformational analysis of 4-amido-2,4-dimethylbutyric acid derivatives
Hoffmann, Reinhard W.,Caturla, Francisco,Lazaro, Miguel A.,Framery, Eric,Bernabeu, M. Carmen,Valancogne, Ingrid,Montalbetti, Christian A. G. N.
, p. 187 - 194 (2007/10/03)
Both syn- and anti-4-amido-2,4-dimethylbutyric acid derivatives 5 and 6 were found to populate a conformation in which the amido group is gauche to the main chain of the molecule. In the anti series (6) a single conformation predominates, in which the acid carbonyl group is also gauche to the main chain. In the syn series (5) two local conformers prevail about the C-2-C-3 bond.
