132533-03-0

Basic information

• Product Name: 3-phenyl-2-hydroperoxybut-3-en-1-ol
• Synonyms: 3-phenyl-2-hydroperoxybut-3-en-1-ol
• CAS NO: 132533-03-0
• Molecular Weight: 180.203
• Mol File: 132533-03-0.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: 3-phenyl-2-hydroperoxybut-3-en-1-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 3-phenyl-2-hydroperoxybut-3-en-1-ol(132533-03-0)
• EPA Substance Registry System: 3-phenyl-2-hydroperoxybut-3-en-1-ol(132533-03-0)

Safety Data

• Hazardous Substances Data: 132533-03-0(Hazardous Substances Data)

Upstream product

• 54976-37-3 3-phenylbut-2-en-1-ol 
• 945-93-7 ethyl (E)-3-phenylbut-2-enoate 
• 54976-38-4 (E)-3-phenylbut-2-en-1-ol 

Downstream Products

• 1415548-72-9 C₃₅H₅₀O₅ 
• 868696-20-2 succinic acid mono-[3-(1-phenyl-vinyl)-1,2,5-trioxa-spiro[5.5]undec-9-yl] ester 
• 868696-29-1 2-[3-(1-phenylvinyl)-1,2,5-trioxaspiro[5.5]undec-9-ylidene]propionic acid ethyl ester 
• 868696-27-9 [3-(1-phenyl-vinyl)-1,2,5-trioxa-spiro[5.5]undec-9-ylidene]-acetic acid ethyl ester 
• 868696-17-7 3-(1-phenyl-vinyl)-1,2,5-trioxa-spiro[5.5]undecan-9-ol 
• 678967-25-4 3-(1-Phenyl-vinyl)-1,2,5-trioxaspiro[5.5]undec-9-one 
• 132533-04-1 3,3-Dimethyl-6-(1-phenyl-vinyl)-[1,2,4]trioxane 
• 132533-06-3 (3R,6R)-3-(4-Methoxy-phenyl)-6-(1-phenyl-vinyl)-[1,2,4]trioxane 
• 132533-05-2 3-(1-Phenyl-vinyl)-1,2,5-trioxa-spiro[5.5]undecane 

Relevant articles and documents

Bile acid-based 1,2,4-trioxanes: Synthesis and antimalarial assessment(1)

A new series of bile acid-based trioxanes 23a-d, 24a-d, 25a-d, 26a, 26b, and 26d have been synthesized and assessed for their antimalarial activity against multidrug-resistant Plasmodium yoelii in Swiss mice by oral route. The antimalarial activity of these trioxanes showed a strong dependence on the side-chain length; shortening side-chain length lead to increase in activity. The antimalarial activity also showed even stronger dependence on the stereochemistry at C3 and C6 (C21 in Figure 5) of the trioxane moiety. Of the two diastereomers isolated of each of the trioxanes, more polar one was significantly more active than the less polar one. The more polar diastereomer of the trioxanes 26a, 26b, and 26d, were the most active compounds of the series. All these three trioxanes provided 100% protection at 24 mg/kg × 4 days. In this model β-arteether provided 100% and 20% protection at 48 mg/kg × 4 days and 24 mg/kg × 4 days, respectively.

Orally active antimalarials: Synthesis and bioevaluation of a new series of steroid-based 1,2,4-trioxanes against multi-drug resistant malaria in mice

A new series of steroid-based 1,2,4-trioxanes 7a-f, 8a-f and 9b-e have been synthesized and evaluated for their antimalarial activity against multi-drug resistant Plasmodium yoelii in Swiss mice by oral route. The biological activity shows a strong depend

Orally active 1,2,4-trioxanes: Synthesis and antimalarial assessment of a new series of 9-functionalized 3-(1-arylvinyl)-1,2,5-trioxaspiro[5.5]undecanes against multi-drug-resistant Plasmodium yoelii nigeriensis in mice

Using easily accessible keto-trioxanes 7a-g as the starting materials, a series of new variously functionalized 1,2,4-trioxanes 10-36 have been prepared and evaluated for antimalarial activity against multi-drug-resistant Plasmodium yoelii nigeriensis in