868696-29-1Relevant articles and documents
Novel spiro-1,2,4-trioxanes
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Page/Page column 84 percent, (2008/06/13)
The present invention relates to spiro 1,2,4-trioxanes of general formula 4. This invention more particularly relates to a process for the preparation of a series of spiro 1,2,4-trioxanes. Wherein, Ar represents aryl groups such as phenyl, 4-biphenyl, 4-c
New orally active spiro 1,2,4-trioxanes with high antimalarial potency
Singh, Chandan,Malik, Heetika,Puri, Sunil K.
, p. 4484 - 4487 (2007/10/03)
A new series of functionalized 1,2,4-trioxanes 10-21 have been prepared and assessed for antimalarial activity in mice. Several of these trioxanes show significant activity. Trioxane 16, the most active compound of the series, has shown activity by oral r