132646-34-5

Basic information

• Product Name: 5-Benzofurancarboxaldehyde, 2-[(5-methyl-2-phenyl-4-oxazolyl)methyl]-
• CAS NO: 132646-34-5
• Molecular Formula: C20H15NO3
• Molecular Weight: 317.344
• Mol File: 132646-34-5.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: 5-Benzofurancarboxaldehyde, 2-[(5-methyl-2-phenyl-4-oxazolyl)methyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Benzofurancarboxaldehyde, 2-[(5-methyl-2-phenyl-4-oxazolyl)methyl]-(132646-34-5)
• EPA Substance Registry System: 5-Benzofurancarboxaldehyde, 2-[(5-methyl-2-phenyl-4-oxazolyl)methyl]-(132646-34-5)

Safety Data

• Hazardous Substances Data: 132646-34-5(Hazardous Substances Data)

Upstream product

• 6813-61-2 2-(benzoylamino)-4-pentynoic acid 
• 132672-20-9 5-bromo-α-(5-methyl-2-phenyloxazol-4-yl)-2-benzofuranmethanol 
• 132646-31-2 (5-bromo-2-benzofuranyl)(5-methyl-2-phenyl-4-oxazolyl)methanone 
• 132646-32-3 2-[(2-Phenyl-5-methyloxazol-4-yl)methyl]-5-bromobenzofuran 
• 103788-62-1 4-bromoacetyl-5-methyl-2-phenyl-oxazole 
• 60032-63-5 4-hydroxy-3-iodo-benzaldehyde 
• 140130-10-5 5-methyl-2-phenyl-4-(2-propynyl)oxazole 
• 132646-33-4 2-<(5-methyl-2-phenyl-4-oxazolyl)methyl>benzofuran-5-carbonitrile 
• 140130-09-2 4-benzoylamino-1-hexyn-5-one 
• 1761-61-1 5-bromosalicyclaldehyde 

Downstream Products

• 140130-21-8 (S)-4-Benzyl-3-{(2S,3R)-2-ethoxy-3-hydroxy-3-[2-(5-methyl-2-phenyl-oxazol-4-ylmethyl)-benzofuran-5-yl]-propionyl}-oxazolidin-2-one 
• 174258-63-0 1-[2-(5-methyl-2-phenyloxazol-4-ylmethyl)benzofuran-5-yl]ethanone 
• 1026734-02-0 N-[2-(5-methyl-2-phenyl-oxazol-4-ylmethyl)-benzofuran-5-ylmethyl]-hydroxylamine 
• 132646-44-7 5-<2-<<(5-methyl-2-phenyl-4-oxazolyl)methyl>-5-benzofuranyl>methylidene>-2,4-oxazolidinedione 
• 132646-45-8 5-(2-(5-methyl-2-phenyloxazol-4-ylmethyl)-benzofuran-5-ylmethyl)-oxazolidine-2,4-dione 
• 140130-15-0 (Z)-3-[2-((5-Methyl-2-phenyl-4-oxazolyl)-methyl)benzofuran-5-yl]-2-methoxy-2-propenenitrile 
• 867-13-0 diethoxyphosphoryl-acetic acid ethyl ester 
• 159017-57-9 ethyl (E)-3-[2-(5-methyl-2-phenyl-4-oxazolylmethyl)benzofuran-5-yl]acrylate 
• 150563-65-8 (E)-3-[2-(5-methyl-2-phenyl-4-oxazolyl)methyl-5-benzofuranyl]-2-phenoxy-2-propenenitrile 
• 140130-22-9 5-{(S)-2-Ethoxy-3-[(S)-4-benzyl-2-oxo-3-oxazolidinyl]-3-oxopropyl}-2-[(5-methyl-2-phenyl-4-oxazolyl)methyl]benzofuran 
• 1027301-79-6 4-[5-(2,2-Bis-benzyloxy-ethyl)-benzofuran-2-ylmethyl]-5-methyl-2-phenyl-oxazole 
• 1027576-13-1 3-{1-(3-Hydroxy-propoxy)-2-[2-(5-methyl-2-phenyl-oxazol-4-ylmethyl)-benzofuran-5-yl]-ethoxy}-propan-1-ol 

Relevant articles and documents

Antihyperglycemic activity of new 1,2,4-oxadiazolidine-3,5-diones

A series of 1,2,4-oxadiazolidine-3,5-diones was synthesized and evaluated as oral antihyperglycemic agents in the obese insulin resistant db/db and ob/ob mouse - the two models for Type 2 diabetes mellitus. The majority of the prepared methoxy- and ethoxy-linked oxazole 1,2,4-oxadiazolidine-3,5-diones normalized plasma glucose levels at the 100 mg kg-1 oral dose in the db/db diabetic mouse model, and several amongst them reduced the glucose levels at the 20 mg kg-1 oral dose. The most potent compounds in the db/db mouse model were also active in the ob/ob mouse model normalizing the plasma glucose levels at the 20 mg kg-1 oral dose. The trifluoromethoxy analog 32 was the most active compound of the series, reducing significantly the plasma glucose levels at the 5 mg kg-1 oral dose. Oxadiazole-tailed 1,2,4-oxadiazolidine-3,5-diones were also active in both the db/db and ob/ob diabetic mouse models normalizing plasma glucose levels at the 100 mg kg-1 oral dose.

Oxazolidinedione hypoglycemic agents

Compounds of the formulae STR1 where R is cycloalkyl or aryl; R1 is alkyl, X is O or C=O; A is O or S; and B is N or CH are useful as hypoglycemic agents.

3-aryl-2-hydroxypropionic acid derivatives and analogs as antihypertensives

A method of using certain 3-aryl-2-hydroxypropionic acid derivatives and analogs in the treatment of hypertension.