1329171-58-5

Basic information

• Product Name: benzyl 2-bromo-5-nitrobenzyl(methyl)carbamate
• Synonyms: benzyl 2-bromo-5-nitrobenzyl(methyl)carbamate
• CAS NO: 1329171-58-5
• Molecular Weight: 379.21
• Mol File: 1329171-58-5.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: benzyl 2-bromo-5-nitrobenzyl(methyl)carbamate(CAS DataBase Reference)
• NIST Chemistry Reference: benzyl 2-bromo-5-nitrobenzyl(methyl)carbamate(1329171-58-5)
• EPA Substance Registry System: benzyl 2-bromo-5-nitrobenzyl(methyl)carbamate(1329171-58-5)

Safety Data

• Hazardous Substances Data: 1329171-58-5(Hazardous Substances Data)

Upstream product

• 6630-33-7 ortho-bromobenzaldehyde 
• 84459-32-5 2-bromo-5-nitrobenzaldehyde 
• 1037082-28-2 1-(2-bromo-5-nitrophenyl)-N-methylmethanamine 
• 501-53-1 benzyl chloroformate 
• 13139-17-8 N-(Benzyloxycarbonyloxy)succinimide 

Relevant articles and documents

Synthesis and P1′ SAR exploration of potent macrocyclic tissue factor-factor VIIa inhibitors

Selective tissue factor-factor VIIa complex (TF-FVIIa) inhibitors are viewed as promising compounds for treating thrombotic disease. In this contribution, we describe multifaceted exploratory SAR studies of S1′-binding moieties within a macrocyclic chemotype aimed at replacing cyclopropyl sulfone P1′ group. Over the course of the optimization efforts, the 1-(1H-tetrazol-5-yl)cyclopropane P1′ substituent emerged as an improved alternative, offering increased metabolic stability and lower clearance, while maintaining excellent potency and selectivity.