133261-17-3

Basic information

• Product Name: (R)-2-(2-ethoxyphenoxy)-N-[2-(4-methoxy-3-aminosulfonyl-phenyl)-1-methyl-ethyl]-acetamide
• Synonyms: (R)-2-(2-ethoxyphenoxy)-N-[2-(4-methoxy-3-aminosulfonyl-phenyl)-1-methyl-ethyl]-acetamide
• CAS NO: 133261-17-3
• Molecular Weight: 422.502
• Mol File: 133261-17-3.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (R)-2-(2-ethoxyphenoxy)-N-[2-(4-methoxy-3-aminosulfonyl-phenyl)-1-methyl-ethyl]-acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-2-(2-ethoxyphenoxy)-N-[2-(4-methoxy-3-aminosulfonyl-phenyl)-1-methyl-ethyl]-acetamide(133261-17-3)
• EPA Substance Registry System: (R)-2-(2-ethoxyphenoxy)-N-[2-(4-methoxy-3-aminosulfonyl-phenyl)-1-methyl-ethyl]-acetamide(133261-17-3)

Safety Data

• Hazardous Substances Data: 133261-17-3(Hazardous Substances Data)

Usage

General Description

The chemical (R)-2-(2-ethoxyphenoxy)-N-[2-(4-methoxy-3-aminosulfonyl-phenyl)-1-methyl-ethyl]-acetamide is a compound with a complex structure. It contains an acetamide group and an ethoxyphenoxy group, as well as a substituted sulfonamide and a methyl-ethyl side chain. This chemical may have potential pharmaceutical or biological applications due to its structural features, which could contribute to specific interactions with biological targets. Further research is needed to fully understand the potential uses and properties of this compound.

Upstream product

• 112101-81-2 5-((R)-2-amino-1-propyl)-2-methoxybenzenesulphonamide 
• 94-71-3 2-Ethoxyphenol 

Downstream Products

• 106133-20-4 tamsulosin hydrochloride 
• 133261-19-5 tamsulosin hydrochloride 
• 106133-20-4 (R)-tamsulosin 

Relevant articles and documents

A PROCESS FOR THE PREPARATION OF R (-) TAMSULOSIN HYDROCHLORIDE

The invention discloses a process for the preparation of highly pure R (-)-5-(2-(2-(2-ethoxy phenoxy) ethylamine) propyl)-2-methoxy benzene sulfonamide hydrochloride used to treat symptoms of urinary difficulty. R-(-)-2-(4-methoxy phenyl)- 1 -methyl ethyl amine is condensed with halo-acetyl halide in the presence of base and a halogenated solvent. The resulting R-(-)- halo-N-[2-(4-methoxy phenyl)- 1 -methyl ethyl] acetamide is treated with chlorosulphonic acid and ammonia. R-(-)-N-[2-(3-amino sulfonyl-4-methoxy phenyl)- 1 -methyl ethyl]-2- haloacetamide obtained is treated with 2- ethoxy phenol in the presence of an inorganic base and water to obtain R-(-)-N-[2-(3-amino sulfonyl-4-methoxy phenyl)- 1 -methyl ethyl]-2-(2- ethoxy phenoxy) acetamide in high yield and purity. The amide obtained is reduced to obtain the Tamsulosin base, which is then purified and converted to its hydrochloride salt.

METHOD OF PREPARING OPTICALLY PURE PHENETHYLAMINE DERIVATIVES

Provided is a method of preparing an optically pure compound having formula 1 or its salts. The method includes: reacting -2-(4-methoxy-3-aminosulfonyl-phenyl)-1-methylethylamine or its salts with a compound selected form the group consisting of chloroacetic acid, bromoacetic acid, fluoroacetic acid, iodoacetic acid, α-halogenoacetic acid anhydride, and α-halogenoacetyl halide in the presence of a base or an acylating agent.