1337570-34-9

Basic information

• Product Name: 2-{[(4S,5R)-4-benzyl-2-oxo-1,3-oxazolidin-5-yl]methyl}-2,3,4,5-tetrahydro-1H-1 λ6,2-benzothiazepine-1,1-dione
• CAS NO: 1337570-34-9
• Molecular Weight: 386.472
• Mol File: 1337570-34-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-{[(4S,5R)-4-benzyl-2-oxo-1,3-oxazolidin-5-yl]methyl}-2,3,4,5-tetrahydro-1H-1 λ6,2-benzothiazepine-1,1-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 2-{[(4S,5R)-4-benzyl-2-oxo-1,3-oxazolidin-5-yl]methyl}-2,3,4,5-tetrahydro-1H-1 λ6,2-benzothiazepine-1,1-dione(1337570-34-9)
• EPA Substance Registry System: 2-{[(4S,5R)-4-benzyl-2-oxo-1,3-oxazolidin-5-yl]methyl}-2,3,4,5-tetrahydro-1H-1 λ6,2-benzothiazepine-1,1-dione(1337570-34-9)

Safety Data

• Hazardous Substances Data: 1337570-34-9(Hazardous Substances Data)

Upstream product

• 851297-52-4 N-allyl-2-bromobenzenesulfonamide 
• 2905-25-1 o-bromobenzenesulfonyl chloride 
• 1337570-31-6 2,3,4,5-tetrahydro-1H-1λ6,2-benzothiazepine-1,1-dione 
• 530-62-1 1,1'-carbonyldiimidazole 
• 1301767-82-7 tert-butyl N-[(1S,2R)-1-benzyl-3-(1,1-dioxo-1,3,4,5-tetrahydro-2H-1λ6,2-benzothiazepin-2-yl)-2-hydroxypropyl]carbamate 

Relevant articles and documents

Design, synthesis, and X-ray crystallographic analysis of a novel class of Hiv-1 protease inhibitors

In the present paper, design, synthesis, X-ray crystallographic analysis, and HIV-1 protease inhibitory activities of a novel class of compounds are disclosed. Compounds 28-30, 32, 35, and 40 were synthesized and found to be inhibitors of the HIV-1 protease. The crucial step in their synthesis involved an unusual endo radical cyclization process. Absolute stereochemistry of the three asymmetric centers in the above compounds have been established to be (4S,2′R,3′S) for optimal potency. X-ray crystallographic analysis has been used to determine the binding mode of the inhibitors to the HIV-1 protease.