851297-52-4Relevant articles and documents
Regioselectivity in the intramolecular heck reaction of a series of cyclic sulfonamides: An experimental and computational study
Geoghegan, Kimberly,Evans, Paul,Rozas, Isabel,Alkorta, Ibon
, p. 13379 - 13387 (2012)
Regioselectivity in the intramolecular Heck reaction of a series of N-sulfonyl-2,5-dihydro-3-substituted pyrroles was studied. These substrates are unbiased in terms of the formed ring size of the new heterocycle. Results indicate that high levels of regi
Design, synthesis, and X-ray crystallographic analysis of a novel class of Hiv-1 protease inhibitors
Ganguly, Ashit K.,Alluri, Sesha S.,Caroccia, Danielle,Biswas, Dipshikha,Wang, Chih-Hung,Kang, Eunhee,Zhang, Yong,McPhail, Andrew T.,Carroll, Steven S.,Burlein, Christine,Munshi, Vandna,Orth, Peter,Strickland, Corey
experimental part, p. 7176 - 7183 (2011/12/04)
In the present paper, design, synthesis, X-ray crystallographic analysis, and HIV-1 protease inhibitory activities of a novel class of compounds are disclosed. Compounds 28-30, 32, 35, and 40 were synthesized and found to be inhibitors of the HIV-1 protease. The crucial step in their synthesis involved an unusual endo radical cyclization process. Absolute stereochemistry of the three asymmetric centers in the above compounds have been established to be (4S,2′R,3′S) for optimal potency. X-ray crystallographic analysis has been used to determine the binding mode of the inhibitors to the HIV-1 protease.
Synthesis of polycyclic lactams and sultams by a cascade ring-closure metathesis/isomerization and subsequent radical cyclization
Bressy, Cyril,Menant, Christine,Piva, Olivier
, p. 577 - 582 (2007/10/03)
Starting from readily available substrates, a new one-pot procedure has been devised to prepare polycyclic lactams and sultams. 2-Pyrrolines obtained from N,N-bisallylamides by ring-closure metathesis and subsequent isomerization promoted by ruthenium hyd
