133972-64-2

Basic information

• Product Name: 5-Thiazolecarboxylic acid, 2-(phenylamino)-, methyl ester
• CAS NO: 133972-64-2
• Molecular Formula: C11H10N2O2S
• Molecular Weight: 234.279
• Mol File: 133972-64-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 5-Thiazolecarboxylic acid, 2-(phenylamino)-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Thiazolecarboxylic acid, 2-(phenylamino)-, methyl ester(133972-64-2)
• EPA Substance Registry System: 5-Thiazolecarboxylic acid, 2-(phenylamino)-, methyl ester(133972-64-2)

Safety Data

• Hazardous Substances Data: 133972-64-2(Hazardous Substances Data)

Upstream product

• 72605-86-8 2-chlorothiazole-5-carboxylic acid methyl ester 
• 62-53-3 aniline 
• 51579-10-3 methyl 2-chloro-3-hydroxypropenoate 
• 103-85-5 monophenylthiourea 
• 20656-61-5 methyl 2-chloro-3-oxopropionate 

Downstream Products

• 133972-63-1 2-phenylaminothiazole-5-carboxylic acid 

Relevant articles and documents

Tyrosine kinase inhibitors

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Studies on Decarboxylation Reactions. Part 7. Kinetic Study of the Decarboxylation of 2-Amino- and 2-Phenylamino-thiazole-5-carboxylic Acids

The rate constants of the decarboxylation reaction of 2-amino- and 2-phenylamino-thiazole-5-carboxylic acid (3a-b), and, for comparison, of 5-phenylamino-1,3,4-thiadiazole-2-carboxylic acid (2b) have been measured in water over a range of proton activities.The results obtained suggest: (i) compound 2b decarboxylates, in the whole range of proton activity studied, through a unimolecular decarboxyprotonation mechanism characteristic of 1,3,4-oxa- and 1,3,4-thiadiazole derivatives; (ii) in contrast, 3a-b decarboxylate via either a unimolecular decarboxyprotonation or a bimolecular protiodecarboxylation mechanism as a function of proton activity.