1339838-72-0Relevant articles and documents
Synthesis of β-Trifluoromethylated Ketones from Propargylic Alcohols by Visible Light Photoredox Catalysis
Park, Sehyun,Joo, Jung Min,Cho, Eun Jin
, p. 4093 - 4097 (2015)
Regioselective trifluoromethylation at a remote position represents an important challenge in the development of biologically active molecules and functional materials. A practical method to access β-trifluoromethyl ketones from readily available propargylic alcohols by visible light photocatalysis has been developed. Trifluoromethylation of propargylic alcohols with CF3I in the presence of Ru(bpy)3Cl2 as the photocatalyst followed by double-bond migration/keto-enol tautomerization provides β-trifluoromethyl ketones as the final product. β-Trifluoromethyl ketones are synthesized from readily available propargylic alcohols by visible light photocatalysis. Trifluoromethylation followed by double-bond migration/keto-enol tautomerization provides β-trifluoromethyl ketones as the final product.
Preparation method of 1-aryl-4,4,4-trifluoro-1-butanone compound
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Paragraph 0047; 0066-0068, (2018/11/10)
The invention relates to a preparation method of a 1-aryl-4,4,4-trifluoro-1-butanone compound and belongs to the field of compound preparation. The preparation method is characterized by comprising the following steps of by taking trifluoromethyl-substituted enol sulfonate as a compound shown in a general formula II as a raw material, synthesizing 1-aryl-4,4,4-trifluoro-1-butanone as a compound shown in a general formula I: the formula l is shown in the description. The method provided by the invention provides a method which is convenient and is low in cost for synthesis of the 1-aryl-4,4,4-trifluoro-1-butanone compound and avoids using an expensive metal catalyst reagent.
Free-Radical-Promoted Copper-Catalyzed Decarboxylative Alkylation of α,β-Unsaturated Carboxylic Acids with ICH2CF3 and Its Analogues
Zhu, Yan,Gong, Juwen,Wang, Yonghui
, p. 7428 - 7436 (2017/07/26)
A novel and efficient free-radical-promoted copper-catalyzed decarboxylative alkylation of α,β-unsaturated carboxylic acids with ICH2CF3 and its analogues has been developed. This methodology provides a convenient access to the synthesis of allylic trifluoromethyl and β-CF3 ketone containing compounds as well as other biologically useful fluorinated molecules and materials.