134019-73-1

Basic information

• Product Name: TERT-BUTYL 2-(CHLOROSULFONYL)ETHYLCARBAMATE
• Synonyms: TERT-BUTYL 2-(CHLOROSULFONYL)ETHYLCARBAMATE;(2-Chlorosulfonyl-ethyl)-carbaMic acid tert-butyl ester
• CAS NO: 134019-73-1
• Molecular Formula: C₇H₁₄ClNO₄S
• Molecular Weight: 243.70836
• Mol File: 134019-73-1.mol
• Article Data: 15

Chemical Properties

• Boiling Point: 337.4±25.0 °C(Predicted)
• Appearance: /
• Density: 1.290±0.06 g/cm3(Predicted)
• PKA: 11.17±0.46(Predicted)
• CAS DataBase Reference: TERT-BUTYL 2-(CHLOROSULFONYL)ETHYLCARBAMATE(CAS DataBase Reference)
• NIST Chemistry Reference: TERT-BUTYL 2-(CHLOROSULFONYL)ETHYLCARBAMATE(134019-73-1)
• EPA Substance Registry System: TERT-BUTYL 2-(CHLOROSULFONYL)ETHYLCARBAMATE(134019-73-1)

Safety Data

• Hazardous Substances Data: 134019-73-1(Hazardous Substances Data)

Usage

Description

TERT-BUTYL 2-(CHLOROSULFONYL)ETHYLCARBAMATE is a chemical compound characterized by the molecular formula C8H15ClNOSO3. It is a carbamate derivative featuring a tert-butyl group and a chlorosulfonyl group attached to an ethyl carbamate moiety. TERT-BUTYL 2-(CHLOROSULFONYL)ETHYLCARBAMATE is known for its versatile applications in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds, as well as its utility as a reagent in organic chemistry reactions, particularly in the preparation of carbamate derivatives.

Uses

Used in Pharmaceutical Synthesis:
TERT-BUTYL 2-(CHLOROSULFONYL)ETHYLCARBAMATE is used as a key intermediate in the synthesis of various pharmaceuticals for its ability to facilitate the formation of carbamate derivatives, which are essential in the development of new drugs.
Used in Agrochemical Production:
In the agrochemical industry, TERT-BUTYL 2-(CHLOROSULFONYL)ETHYLCARBAMATE is utilized as a precursor in the production of pesticides and other agrochemicals, contributing to the development of effective crop protection agents.
Used in Organic Chemistry Reactions:
TERT-BUTYL 2-(CHLOROSULFONYL)ETHYLCARBAMATE serves as a reagent in organic chemistry, particularly for the preparation of carbamate derivatives. Its unique structure allows for specific reactions that are valuable in the synthesis of complex organic molecules.
Used in Chemical Manufacturing:
TERT-BUTYL 2-(CHLOROSULFONYL)ETHYLCARBAMATE finds application in the chemical manufacturing industry, where it is employed in the production of various organic compounds, showcasing its versatility and importance in the synthesis of a wide range of products.

Upstream product

• 107-35-7 Tau 
• 24424-99-5 di-tert-butyl dicarbonate 
• 122234-46-2 2-iodo-1-<(tert-butyloxycarbonyl)amino>ethane 
• 67385-09-5 2-[(tert-butoxycarbonyl)amino]-1-ethanethiol 
• 168984-74-5 tetrabutylammonium 2-((tert-butoxycarbonyl)amino)ethane-1-sulfonate salt 
• 67385-10-8 di-tert-butyl(disulfanediylbis(ethane-2,1-diyl))dicarbamate 

Downstream Products

• 168984-76-7 [2-(2-Benzylsulfamoyl-ethylsulfamoyl)-ethyl]-carbamic acid tert-butyl ester 
• 1476070-53-7 C₁₅H₂₀F₃NO₅S 
• 213740-69-3 3,5-Bis-[(2-tert-butoxycarbonylamino-ethanesulfonylamino)-methyl]-benzoic acid methyl ester 
• 148200-69-5 N-(tert-butyloxycarbonyl)amino-ethane-sulfonyl-phenylalanine-methylester 
• 168984-75-6 (2-Benzylsulfamoyl-ethyl)-carbamic acid tert-butyl ester 

Relevant articles and documents

Solid-phase synthesis of peptidosulfonamide containing peptides derived from Leu-enkephalin

Using Boc or Fmoc-protected β-substituted aminoethanesulfonyl chlorides (2-substituted taurylchlorides) the solid-phase synthesis of dipeptidosulfonamides as well as peptidosulfonamide containing peptides derived from Leu-enkephalin is described. The binding activity of the peptidosulfonamide YGGFL derivatives is reported.

Helical Antimicrobial Sulfono-γ-AApeptides

Host-defense peptides (HDPs) such as magainin 2 have emerged as potential therapeutic agents combating antibiotic resistance. Inspired by their structures and mechanism of action, herein we report the first example of antimicrobial helical sulfono-γ-AApeptide foldamers. The lead molecule displays broad-spectrum and potent antimicrobial activity against multi-drug-resistant Gram-positive and Gram-negative bacterial pathogens. Time-kill studies and fluorescence microscopy suggest that sulfono-γ-AApeptides eradicate bacteria by taking a mode of action analogous to that of HDPs. Clear structure-function relationships exist in the studied sequences. Longer sequences, presumably adopting more-defined helical structures, are more potent than shorter ones. Interestingly, the sequence with less helical propensity in solution could be more selective than the stronger helix-forming sequences. Moreover, this class of antimicrobial agents are resistant to proteolytic degradation. These results may lead to the development of a new class of antimicrobial foldamers combating emerging antibiotic-resistant pathogens.

TETRAZINES FOR HIGH CLICK RELEASE SPEED AND YIELD

Disclosed herein are tetrazines substituted with groups that result in a high click conjugation yield and high click release yields. In some of several other aspects, the invention relates to combinations and kits comprising said tetrazines and a dienophile, preferably a trans-cyclooctene. In another aspect, the compounds, combinations, and kits are for use as a medicament.

C26-LINKED RAPAMYCIN ANALOGS AS MTOR INHIBITORS

The present disclosure relates to mTOR inhibitors. Specifically, the embodiments are directed to compounds and compositions inhibiting mTOR, methods of treating diseases mediated by mTOR, and methods of synthesizing these compounds.