122234-46-2

Basic information

• Product Name: TERT-BUTYL 2-IODOETHYLCARBAMATE
• Synonyms: TERT-BUTYL 2-IODOETHYLCARBAMATE;(2-Iodo-ethyl)-carbaMic acid tert-butyl ester;2-iodo-1-(tert-butyloxycarbonyl)aminoethane
• CAS NO: 122234-46-2
• Molecular Formula: C₇H₁₄INO₂
• Molecular Weight: 271.1
• Mol File: 122234-46-2.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 281.3±23.0 °C(Predicted)
• Appearance: /
• Density: 1.546±0.06 g/cm3(Predicted)
• Storage Temp.: Keep in dark place,Sealed in dry,Store in freezer, under -20°C
• PKA: 11.93±0.46(Predicted)
• CAS DataBase Reference: TERT-BUTYL 2-IODOETHYLCARBAMATE(CAS DataBase Reference)
• NIST Chemistry Reference: TERT-BUTYL 2-IODOETHYLCARBAMATE(122234-46-2)
• EPA Substance Registry System: TERT-BUTYL 2-IODOETHYLCARBAMATE(122234-46-2)

Safety Data

• Hazardous Substances Data: 122234-46-2(Hazardous Substances Data)

Usage

Uses

tert-Butyl (2-Iodoethyl)carbamate can be used as antiviral agents.

Upstream product

• 288-32-4 1H-imidazole 
• 26690-80-2 2-(N-tert-butoxycarbonylamino)ethanol 
• 7553-56-2 iodine 
• 24424-99-5 di-tert-butyl dicarbonate 
• 39684-80-5 2-(tert-butoxycarbonylamino)ethyl bromide 

Downstream Products

• 38427-90-6 N-(t-butoxycarbonyl)phenethylamine 
• 144226-16-4 (tert-butoxy)-N-[2-(4-nitrophenyl)-ethyl]-carboxamide 
• 134019-73-1 ?tert-butyl [2-(chlorosulfonyl)ethyl]carbamate 
• 67385-09-5 2-[(tert-butoxycarbonyl)amino]-1-ethanethiol 
• 921596-28-3 tert-butyl (2-phenoxyethyl)carbamate 
• 1228662-37-0 ethyl 1-benzyl-3-(2-(tert-butoxycarbonylamino)ethyl)-5-hydroxy-2-oxoindoline-3-carboxylate 
• 363599-38-6 N-(tert-Butoxycarbonyl)penta-3,4-dienylamine 

Relevant articles and documents

Fluorodibenzocyclooctynes: A Trackable Click Reagent with Enhanced Reactivity

Bioorthogonal reactions have widespread applications in biological systems, and development of new bioorthogonal reactions has been of great interest over the past two decades. In this work, the design and synthesis of a family of fluorinated dibenzocyclooctynes (FDIBOs) are reported. The electron-deficient nature of fluorine atoms significantly accelerated the reaction of cyclooctynes in 1,3-dipolar cycloadditions, with either benzyl azide or ethyl diazoacetate, compared to conventional dibenzocyclooctyne (DIBO). In addition, FDIBOs showed unique trackable properties owing to the high NMR sensitivity of the naturally abundant 19F isotope. Biological molecules, including a monosaccharide, a peptide, and a protein, were tested with FDIBOs, and these reactions could be easily monitored by 19F NMR spectroscopy to evaluate the progress of the conjugation reactions. In addition, labeling of live cells was also demonstrated with metabolically modified bacteria to expand the possible applications of FDIBOs.

Thiomaleic anhydride: A convenient building block for the synthesis of α-substituted γ- and δ-lactones through free-radical addition, nucleophilic ring opening, and subsequent thiocarboxylate manipulation

(Chemical Equation Presented) Iodoalkyl tert-butyl carbonates and carbamates undergo clean free-radical addition to thiomaleic anhydride to give substituted thiosuccinic anhydrides in high yield on treatment with tris-(trimethylsilyl)silane and a radical initiator. After removal of the tert-butyloxycarbonyl group, cyclization then affords lactones or lactams substituted in the α-position by a thiocarboxylic acid residue. This group is converted to amides through reaction with electron-deficient sulfonamides or to aldehydes and/or ketones by the reaction of derived thioesters with either thiophenol, an electron-deficient allyl phenyl sulfide, or phenylboronic acid.

ALKOXY SUBSTITUTED IMIDAZOQUINOLINES

Imidazoquinoline compounds with an alkoxy substituent at the 6, 7, 8, or 9-position, pharmaceutical compositions containing the compounds, intermediates, methods of making, and methods of use of these compounds as immunomodulators, for inducing or inhibit