134022-08-5

Basic information

• Product Name: 2-(4-nitrophenyl)-3-acetyl-5-phenyl-2,3-dihydro-1,3,4-oxadiazole
• Synonyms: 2-(4-nitrophenyl)-3-acetyl-5-phenyl-2,3-dihydro-1,3,4-oxadiazole
• CAS NO: 134022-08-5
• Molecular Weight: 311.297
• Mol File: 134022-08-5.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-(4-nitrophenyl)-3-acetyl-5-phenyl-2,3-dihydro-1,3,4-oxadiazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-nitrophenyl)-3-acetyl-5-phenyl-2,3-dihydro-1,3,4-oxadiazole(134022-08-5)
• EPA Substance Registry System: 2-(4-nitrophenyl)-3-acetyl-5-phenyl-2,3-dihydro-1,3,4-oxadiazole(134022-08-5)

Safety Data

• Hazardous Substances Data: 134022-08-5(Hazardous Substances Data)

Upstream product

• 59394-91-1 (E)-N′-(4-nitrobenzylidene)benzohydrazide 
• 108-24-7 acetic anhydride 
• 555-16-8 4-nitrobenzaldehdye 
• 613-94-5 benzoic acid hydrazide 
• 59394-91-1 N-(4-nitrobenzylidene)benzohydrazide 

Downstream Products

• 1090-82-0 2-(4-nitrophenyl)-5-phenyl-1,3,4-oxadiazole 

Relevant articles and documents

3-Acetyl-2,5-diaryl-2,3-dihydro-1,3,4-oxadiazoles: A new scaffold for the selective inhibition of monoamine oxidase B

3-Acetyl-2,5-diaryl-2,3-dihydro-1,3,4-oxadiazoles were designed, synthesized, and tested as inhibitors against human monoamine oxidase (MAO) A and B isoforms. Several compounds, obtained as racemates, were identified as selective MAO-B inhibitors. The enantiomers of some derivatives were separated by enantioselective HPLC and tested. The R-enantiomers always showed the highest activity. Docking study and molecular dynamic simulations demonstrated the putative binding mode. We conclude that these 1,3,4-oxadiazoles derivatives are promising reversible and selective MAO-B inhibitors.