1345719-55-2

Basic information

• Product Name: diethyl ((4-broMophenyl)ethynyl)phosphonate
• Synonyms: diethyl ((4-broMophenyl)ethynyl)phosphonate
• CAS NO: 1345719-55-2
• Molecular Weight: 317.119
• Mol File: 1345719-55-2.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: diethyl ((4-broMophenyl)ethynyl)phosphonate(CAS DataBase Reference)
• NIST Chemistry Reference: diethyl ((4-broMophenyl)ethynyl)phosphonate(1345719-55-2)
• EPA Substance Registry System: diethyl ((4-broMophenyl)ethynyl)phosphonate(1345719-55-2)

Safety Data

• Hazardous Substances Data: 1345719-55-2(Hazardous Substances Data)

Usage

General Description

Diethyl ((4-bromophenyl)ethynyl)phosphonate is a chemical compound with the molecular formula C12H13BrO2P. It is commonly used as a key intermediate in the synthesis of pharmaceutical compounds and agrochemicals. diethyl ((4-broMophenyl)ethynyl)phosphonate belongs to the class of organophosphorus compounds, which are widely used in various industrial processes. It is important to handle diethyl ((4-bromophenyl)ethynyl)phosphonate with caution, as it can be harmful if ingested or if it comes into contact with skin or eyes. Additionally, it is important to store this compound in a cool, dry place and handle it in a well-ventilated area to avoid potential health hazards.

Upstream product

• 136350-66-8 1-bromo-4-(2,2-dibromovinyl)benzene 
• 122-52-1 triethyl phosphite 
• 766-96-1 4-bromo-1-ethynylbenzene 
• 762-04-9 phosphonic acid diethyl ester 
• 934-94-1 1-bromo-4-bromoethynyl-benzene 
• 18276-83-0 (2-oxo-(2-p-bromophenyl)ethyl)phosphonic acid diethyl ester 
• 99-73-0 para-bromophenacyl bromide 

Downstream Products

• 1571900-39-4 2-ethoxy-4-(4-bromophenyl)-1,2λ⁵-benzoxaphosphinine 2-oxide 
• 18276-83-0 (2-oxo-(2-p-bromophenyl)ethyl)phosphonic acid diethyl ester 

Relevant articles and documents

Rhodium(I)-Catalyzed Azide-Alkyne Cycloaddition (RhAAC) of Internal Alkynylphosphonates with High Regioselectivities under Mild Conditions

A regioselective method to access fully substituted 1,2,3-triazolyl-4-phosphonates from the internal alkynylphosphonates by rhodium(I)-catalyzed azide-alkyne cycloaddition (RhAAC) under mild conditions is reported. This approach is water and air compatible and has a broad substrate scope, good functional group tolerance, high yields and excellent regioselectivities. Fully substituted 1,2,3-triazolyl-4-phosphonates are directly prepared from the internal alkynylphosphonates by RhAAC with high 1,4-regioselectivities. The gram-scale preparation, application to carbohydrate synthesis and the solid-phase synthesis of triazolyl-4-phosphonates are highlights of this method. (Figure presented.).

Synthesis method of P-alkynyl phosphate compound

The invention relates to a synthesis method of a P-alkynyl phosphate compound. The synthesis method comprises the following steps: enabling a P-acylethyl phosphate compound, pyridinium salt and organic alkali to react with one another in an organic solven

Mukaiyama reagent-promoted metal-free preparation of alkynyl sulfones and phosphonates under mild conditions

An efficient and mild route for the formation sulfur or phosphor-substituted alkynes was herein demonstrated. The Mukaiyama reagent-mediated transformation started from easily-accessible substrates without carbon-carbon triple bonds, and the reaction proceeded under mild conditions (room temperature) in a one-pot manner, requiring for no transition metal-catalysts. The practical protocol featured for good functional groups tolerance (up to 41 examples) and high efficiency (up to 91% yields) towards alkynyl sulfones and alkynyl phosphonates at low cost.