18276-83-0

Basic information

• Product Name: (2-oxo-(2-p-bromophenyl)ethyl)phosphonic acid diethyl ester
• Synonyms: (2-oxo-(2-p-bromophenyl)ethyl)phosphonic acid diethyl ester
• CAS NO: 18276-83-0
• Molecular Weight: 335.134
• Mol File: 18276-83-0.mol
• Article Data: 25

Chemical Properties

• CAS DataBase Reference: (2-oxo-(2-p-bromophenyl)ethyl)phosphonic acid diethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (2-oxo-(2-p-bromophenyl)ethyl)phosphonic acid diethyl ester(18276-83-0)
• EPA Substance Registry System: (2-oxo-(2-p-bromophenyl)ethyl)phosphonic acid diethyl ester(18276-83-0)

Safety Data

• Hazardous Substances Data: 18276-83-0(Hazardous Substances Data)

Upstream product

• 99-73-0 para-bromophenacyl bromide 
• 122-52-1 triethyl phosphite 
• 337924-75-1 C₁₀H₁₁BrN₂O₂ 
• 1200-07-3 3-(4-bromophenyl)acrylic acid 
• 762-04-9 phosphonic acid diethyl ester 
• 89108-50-9 1-(1-azidovinyl)-4-bromobenzene 
• 766-96-1 4-bromo-1-ethynylbenzene 
• 5391-88-8 1-(4-bromophenyl)ethanol 
• 4023-81-8 1-(p-bromophenyl)-1,3-butanedione 
• 2039-82-9 1-bromo-4-ethenyl-benzene 
• 683-08-9 Diethyl methylphosphonate 
• 5798-75-4 Ethyl 4-bromobenzoate 
• 762-04-9 Diethyl phosphonate 
• 1200-07-3 trans-4-bromocinnamic acid 

Downstream Products

• 1451191-63-1 C₁₅H₂₁BrNO₃P 
• 1451191-81-3 C₁₅H₂₁BrNO₃P 
• 1451191-83-5 C₁₅H₂₁BrNO₃P 
• 64214-95-5 5-(4-bromo-phenyl)-1-(3-trifluoromethyl-phenyl)-1H-[1,2,3]triazole 
• 1345719-55-2 P-(2-(4-bromophenyl)ethynyl)-diethyl phosphonate 
• 173847-72-8 diethyl 2-(p-bromophenyl)-2-hydrazonoethylphosphonate 

Relevant articles and documents

Copper-Catalyzed Microwave-Expedited Oxyphosphorylation of Alkynes with Diethyl Phosphite and t-Butyl Hydroperoxide Synthesis of Densely Functionalized Phosphonylated Indenones

Treatment of alkynes with diethyl phosphite and t-butyl hydroperoxide in the presence of [Cu(MeCN)4]BF4 under microwave irradiation produced the oxyphosphorylation of the triple bond, giving rise to the corresponding β-ketophosphonates in moderate-to-good yields. When the triple bond was conjugated to a carbonyl group bearing an aromatic ring, it led to the cyclization of the resulting ketone intermediate, producing eventually different phosphonylated indenones.

Mukaiyama reagent-promoted metal-free preparation of alkynyl sulfones and phosphonates under mild conditions

An efficient and mild route for the formation sulfur or phosphor-substituted alkynes was herein demonstrated. The Mukaiyama reagent-mediated transformation started from easily-accessible substrates without carbon-carbon triple bonds, and the reaction proceeded under mild conditions (room temperature) in a one-pot manner, requiring for no transition metal-catalysts. The practical protocol featured for good functional groups tolerance (up to 41 examples) and high efficiency (up to 91% yields) towards alkynyl sulfones and alkynyl phosphonates at low cost.

Silver-Catalyzed Oxidative C(sp3)?P Bond Formation through C?C and P?H Bond Cleavage

The silver-catalyzed oxidative C(sp3)?H/P?H cross-coupling of 1,3-dicarbonyl compounds with H-phosphonates, followed by a chemo- and regioselective C(sp3)?C(CO) bond-cleavage step, provided heavily functionalized β-ketophosphonates. This novel method based on a readily available reaction system exhibits wide scope, high functional-group tolerance, and exclusive selectivity.