134659-18-0

Basic information

• Product Name: N²-(4-chlorophenyl)-6-(4-(trifluoromethyl)phenyl)-1,3,5-triazine-2,4-diamine
• CAS NO: 134659-18-0
• Molecular Weight: 365.745
• Mol File: 134659-18-0.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: N²-(4-chlorophenyl)-6-(4-(trifluoromethyl)phenyl)-1,3,5-triazine-2,4-diamine(CAS DataBase Reference)
• NIST Chemistry Reference: N²-(4-chlorophenyl)-6-(4-(trifluoromethyl)phenyl)-1,3,5-triazine-2,4-diamine(134659-18-0)
• EPA Substance Registry System: N²-(4-chlorophenyl)-6-(4-(trifluoromethyl)phenyl)-1,3,5-triazine-2,4-diamine(134659-18-0)

Safety Data

• Hazardous Substances Data: 134659-18-0(Hazardous Substances Data)

Upstream product

• 455-19-6 4-Trifluoromethylbenzaldehyde 
• 133476-40-1 1-(4-Chloro-phenyl)-3-(4-trifluoromethyl-benzoyl)-thiourea 
• 594-14-9 guanidinium sulfate 
• 133476-21-8 N-[3-(4-Chloro-phenyl)-[1,3]thiazetidin-(2Z)-ylidene]-4-trifluoromethyl-benzamide 
• 106-47-8 4-chloro-aniline 

Relevant articles and documents

6,: N 2-Diaryl-1,3,5-triazine-2,4-diamines: Synthesis, antiproliferative activity and 3D-QSAR modeling

A library of 126 compounds with a 6,N2-diaryl-1,3,5-triazine-2,4-diamine scaffold was prepared using a one-pot, microwave-assisted method from readily available cyanoguanidine, aromatic aldehydes and arylamines. The three-component condensation of these reagents in the presence of hydrochloric acid was followed by the treatment with a base, which promoted a rearrangement of the dihydrotriazine ring and its dehydrogenative aromatization. The antiproliferative properties of the prepared compounds were evaluated using three breast cancer cell lines. The most promising results were obtained in the growth inhibition of the triple negative MDA-MB231 breast cancer cells. The active compounds were also selective against cancer cells and did not affect growth of the non-cancerous MCF-10A breast cell line. Analyzing the structure-activity relationship within the series, we built a 3D-QSAR model for the further design of more potent anticancer compounds.

Synthesis and Reaction of 2-Imino-1,3-thiazetidines and 2-Imino-1,3-dithietanes

2-Imino-1,3-thiazetidines and 2-imino-1,3-dithietanes were synthesized and their reactivities were studied.The former readily underwent ring-opening reaction with amines to yield guanidine derivatives.The reaction products were applied to the synthesis of heterocycles such as triazoles and triazines.The latter was converted to isothiocyanate by the reaction of m-chloroperbenzoic acid.