455-19-6

Basic information

• Product Name: 4-(Trifluoromethyl)benzaldehyde
• Synonyms: A,A,A-TRIFLUORO-P-TOLUALDEHYDE;4-(TRIFLUOROMETHYL)BENZALDEHYDE;4'-TRIFLUOROMETHYL BENZALDEHYDE;P-TRIFLUOROMETHYLBENZALDEHYDE;P-(TRIFLUOROMETHYL)-BENZALDHYDE;PTF-BAD;α,α,α-Trifluoro-p-tolualdehyde ;p-(Trifluoromethyl)benzaldehyde 4-(Trifluoromethyl)benzaldehyde
• CAS NO: 455-19-6
• Molecular Formula: C₈H₅F₃O
• Molecular Weight: 174.12
• EINECS: 207-240-7
• Product Categories: Pharmaceutical Intermediates;Aromatic Aldehydes & Derivatives (substituted);Benzaldehyde;Miscellaneous;organofluorine compounds
• Mol File: 455-19-6.mol
• Article Data: 266

Chemical Properties

• Melting Point: 1-2°C
• Boiling Point: 66-67 °C13 mm Hg(lit.)
• Flash Point: 150 °F
• Appearance: Clear colorless to yellow/Liquid
• Density: 1.275 g/mL at 25 °C(lit.)
• Vapor Pressure: 1.09mmHg at 25°C
• Refractive Index: n20/D 1.463(lit.)
• Storage Temp.: 2-8°C
• Solubility: 1.5g/l
• Water Solubility: Soluble in water. 1.5 g/L at 20°C
• Sensitive: Air Sensitive
• BRN: 1101680
• CAS DataBase Reference: 4-(Trifluoromethyl)benzaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(Trifluoromethyl)benzaldehyde(455-19-6)
• EPA Substance Registry System: 4-(Trifluoromethyl)benzaldehyde(455-19-6)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• F: 10-23
• TSCA: T
• HazardClass: IRRITANT, AIR SENSITIVE
• Hazardous Substances Data: 455-19-6(Hazardous Substances Data)

Usage

Chemical Properties

Clear colorless to yellow liquid

Uses

4-(Trifluoromethyl)benzaldehyde is a reactant that has been used in the preparation of N,N''-(Arylmethylene)bisamides with cytotoxic activity as anti cancer agents.

InChI:InChI=1/C8H5F3O/c9-8(10,11)7-3-1-6(5-12)2-4-7/h1-5H

Upstream product

• 329-15-7 4-trifluoromethyl-phenyl acetyl chloride 
• 79-46-9 2-nitropropane 
• 141-52-6 sodium ethanolate 
• 402-49-3 4-bromomethyltrifluoromethylbenzene 
• 402-51-7 4-(trifluoromethyl)phenylmagnesium bromide 
• 122-51-0 orthoformic acid triethyl ester 
• 2591-86-8 N-Formylpiperidine 
• 98-56-6 4-chlorobenzotrifluoride 
• 93-61-8 N-methyl-N-phenylformamide 
• 402-43-7 p-trifluoromethylphenyl bromide 
• 68-12-2 N,N-dimethyl-formamide 
• 402-50-6 1-trifluoromethyl-4-vinyl-benzene 
• 95725-04-5 N,N-diethyl-4-(trifluoromethyl)benzamide 
• 155820-05-6 4-(trifluoromethyl)benzyl alcohol methyl ether 

Downstream Products

• 34328-31-9 (4-chloro-phenyl)-(4-trifluoromethyl-phenyl)-methanone 
• 2341-32-4 1-methyl-1-nitro-2-<4-(trifluoromethyl)phenyl>ethene 
• 34328-35-3 2,4-Dichlor-4'-trifluormethylbenzophenon 
• 34328-34-2 3,4-Dichlor-4'-trifluormethylbenzophenon 
• 16642-92-5 4-(trifluoromethyl)cinnamic acid 
• 34328-30-8 4-trifluoromethyl-4′-methylbenzophenone 
• 34328-32-0 4-Iod-4'-trifluormethylbenzophenon 
• 34328-38-6 3,4-Dibrom-4'-trifluormethylbenzophenon 
• 34367-37-8 trifluoromethoxy-4 trifluoromethyl-4' benzophenone 
• 34328-39-7 3,4,5-Trichlor-4'-trifluormethylbenzophenon 
• 339566-03-9 4-phenyl-5-(4-trifluoromethyl-phenyl)-4,5-dihydro-oxazole 
• 57260-61-4 2-thioxo-5-(4-trifluoromethyl-phenyl)-oxazolidin-4-one 
• 42134-71-4 1,2-bis(4-(trifluoromethyl)phenyl)ethane 
• 42134-70-3 (Z)-1,2-bis(4-(trifluoromethyl)phenyl)ethene 

Relevant articles and documents

In alkaline media, Fremy's salt oxidizes alkanols by a hydrogen atom transfer mechanism

In aqueous alkali, Fremy's salt (potassium nitrosodisulfonate dimer), homolyses nearly exclusively to the monomer radical anion, nitrosodisulfonate (NDS). In this media, NDS almost quantitatively oxidizes benzyl alcohol (PhCH2OH) to benzaldehyd

A Metal–Organic Framework as a Multiphoton Excitation Regulator for the Activation of Inert C(sp3)?H Bonds and Oxygen

The activation and oxidization of inert C(sp3)?H bonds into value-added chemicals affords attractively economic and ecological benefits as well as central challenge in modern chemistry. Inspired by the natural enzymatic transformation, herein,

Metal-free selective reduction of acid chlorides to aldehydes using 1-hydrosilatrane

This work uses 1-hydrosilatrane – an accessible and easy-to-handle reducing reagent – to selectively reduce acid chlorides to aldehydes. This metal-free reduction proceeds rapidly at ambient temperature in the presence of N-methylpyrrolidine, efficiently producing aldehydes in up to 54% yield and with the balance largely remaining as starting material. No over-reduced alcohol product is observed.