1350619-67-8Relevant articles and documents
Benzoisothiazolone (BIT): A Fast, Efficient, and Recyclable Redox Reagent for Solid Phase Peptide Synthesis
Bukya, Hemalatha,Gangireddy, Pavankumar,Mainkar, Prathama S.,Nayani, Kiranmai
supporting information, p. 5358 - 5362 (2020/08/27)
Solid-phase peptide synthesis (SPPS), a preferred synthetic procedure, generates by-products and effluents in multiple equivalents for one equivalent of desired product. Presented herein is the use of a fast and efficient coupling protocol for SPPS using a benzoisothiazolone (BIT), which can be fully recycled. The BIT, as redox activator, works under very mild conditions and generates minimal amount of waste. As a case study, the BIT coupling protocol is applied to the synthesis of side chain of the recently discovered antibiotic, teixobactin.