1352037-95-6

Basic information

• Product Name: 3-phenyl-2-(pyridin-4-yl)-1,7-naphthyridine
• CAS NO: 1352037-95-6
• Molecular Weight: 283.332
• Mol File: 1352037-95-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-phenyl-2-(pyridin-4-yl)-1,7-naphthyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 3-phenyl-2-(pyridin-4-yl)-1,7-naphthyridine(1352037-95-6)
• EPA Substance Registry System: 3-phenyl-2-(pyridin-4-yl)-1,7-naphthyridine(1352037-95-6)

Safety Data

• Hazardous Substances Data: 1352037-95-6(Hazardous Substances Data)

Upstream product

• 103698-10-8 methyl 3-nitropyridine-4-carboxylate 
• 55279-30-6 methyl 3-aminoisonicotinate 
• 1017-24-9 2-phenyl-1-pyridin-4-yl-ethanone 
• 55279-29-3 3-amino-pyridine-4-carbaldehyde 
• 1352037-93-4 N-methoxy-N-methyl 3-amino-isonicotinamide 
• 2459-09-8 4-pyridinecarboxylic acid, methyl ester 

Relevant articles and documents

Synthesis of novel 1,7-naphthyridines by Friedlaender condensation of pyridine substrates

The general ability of appropriate pyridyl compounds (aldehyde or ketone) to undergo Friedlaender condensation to give different 1,7-naphthyridines has been demonstrated. 2,4-Disubstituted 1,7-naphthyridine 8 was prepared from 3-amino-4-acetylpyridine (6) and ketone 4 (82%). The Friedlaender self-condensation of pyridyl substrate 6 is reported, as well. The dimer product, 2-(3-aminopyridin-4-yl)-4-methyl-1,7-naphthyridine (7), was obtained in 97% yield. 2-Aryl-and 2,3-diaryl-1,7-naphthyridines (16-18) were prepared from 3-aminoisonicotinaldehyde (13) and arylketones 4, 14, and 15 (28-71%). The key substrates 6 and 13 are readily available via the improved pyridine nitration method. Copyright