55279-30-6

Basic information

• Product Name: 3-AMINO-ISONICOTINIC ACID METHYL ESTER
• Synonyms: METHYL 3-AMINOPYRIDINE-4-CARBOXYLATE;METHYL 3-AMINOISONICOTINATE;AKOS 93360;3-AMINO-ISONICOTINIC ACID METHYL ESTER;3-AMINO-4-PYRIDINECARBOXYLIC ACID METHYL ESTER;3-AMINOPYRIDINE-4-CARBOXYLIC ACID METHYL ESTER;3-Amino-isonicotinic acid methyl ester ,98%;Tpc-py003
• CAS NO: 55279-30-6
• Molecular Formula: C₇H₈N₂O₂
• Molecular Weight: 152.15
• EINECS: 1592732-453-0
• Product Categories: pharmacetical;Esters;Pyridines;Pyridine
• Mol File: 55279-30-6.mol
• Article Data: 14

Chemical Properties

• Melting Point: 84-86
• Boiling Point: 292.5 ºC at 760 mmHg
• Flash Point: 130.7 ºC
• Appearance: /
• Density: 1.238 g/cm³
• Vapor Pressure: 0.00183mmHg at 25°C
• Refractive Index: 1.57
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: 4.05±0.18(Predicted)
• CAS DataBase Reference: 3-AMINO-ISONICOTINIC ACID METHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 3-AMINO-ISONICOTINIC ACID METHYL ESTER(55279-30-6)
• EPA Substance Registry System: 3-AMINO-ISONICOTINIC ACID METHYL ESTER(55279-30-6)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 22-36/38
• Safety Statements: 24/25
• Hazardous Substances Data: 55279-30-6(Hazardous Substances Data)

Usage

Chemical Properties

Yellow powder

Uses

3-Aminoisonicotinic Acid Methyl Ester is a useful synthetic intermediate. It is used in the synthesis of morpholinophenylquinazolines and related derivatives as PI3 kinase p110α inhibitors. It is also used to synthesize aryl tetrahydropyridine inhibitors of farnesyltransferase as antitumor agents.

InChI:InChI=1/C7H8N2O2/c1-11-7(10)5-2-3-9-4-6(5)8/h2-4H,8H2,1H3

Upstream product

• 103698-10-8 methyl 3-nitropyridine-4-carboxylate 
• 67-56-1 methanol 
• 7579-20-6 3-Aminopyridine-4-carboxylic acid 
• 18107-18-1 diazomethyl-trimethyl-silane 
• 2459-09-8 4-pyridinecarboxylic acid, methyl ester 
• 4664-01-1 3,4-pyridinedicarboximide 
• 462-08-8 pyridin-3-ylamine 
• 56700-70-0 3-(tert-butoxycarbonylamino)pyridine 
• 179024-65-8 3-tert-butoxycarbonylaminoisonicotinic acid 
• 55-22-1 pyridine-4-carboxylic acid 
• 158063-66-2 4-(trifluoromethyl)nicotinic acid 
• 158062-71-6 4-trifluoromethyl-3-pyridinecarboxamide 

Downstream Products

• 64188-97-2 3-aminopyridine-4-carboxamide 
• 64189-08-8 3-Aminopyridin-4-carboxysaeurehydrazid 
• 10128-72-0 methyl 3-hydroxypyridine-4-carboxylate 
• 188677-49-8 methyl 3-iodo-4-pyridinecarboxylate 
• 153716-51-9 3-(1-pyrrolyl)-pyridine-4-carboxylic acid 
• 883107-62-8 2,6-dichloro-3-amino-4-pyridinecarboxylic acid methyl ester 
• 1352037-95-6 3-phenyl-2-(pyridin-4-yl)-1,7-naphthyridine 
• 55279-29-3 3-amino-pyridine-4-carbaldehyde 
• 58484-01-8 3-amino-2,6-dichloroisonicotinic acid 
• 54920-76-2 [1,7]naphthyridine-2,4-diol 

Relevant articles and documents

Synthesis method of 3-amino methyl isonicotinate

The invention discloses a synthesis method of 3-amino methyl isonicotinate, wherein the synthesis method comprises the steps: by taking 4-trifluoromethyl nicotinic acid as an initial raw material, sequentially carrying out acylation condensation series connection, Hofmann degradation, hydrolysis and esterification reaction to obtain the 3-amino methyl isonicotinate. The synthesis method has the advantages of mild reaction conditions, high yield, low cost, easily available raw materials, and realization of industrial production, the thionyl chloride reaction liquid can be repeatedly used, the utilization rate of the raw materials is improved, the resource waste is reduced, the pollution is reduced, the production cost of the whole process is furthest reduced, and the application value is extremely high.

High-yield synthesis method of methyl 3-aminoisonicotinate

The invention belongs to the field of chemical pharmacy, and particularly discloses a high-yield synthesis method of methyl 3-aminoisonicotinate. According to the high-yield synthesis method, 4-picolinic acid is used as a raw material and subjected to brominating, ammonifying and esterifying to obtain methyl 3-aminoisonicotinate. The high-yield synthesis method of methyl 3-aminoisonicotinate has the advantages of mild reaction conditions, high total yield, realization of repeated use of a 3-bromo-4-picolinic acid reaction waste filtrate, improvement of the utilization rate of the raw material,reduction of resource waste, maximum reduction of the production cost of the whole process, and extremely high application value.

Hofmann-type rearrangement of imides by in situ generation of imide-hypervalent iodines(III) from iodoarenes

The Hofmann-type rearrangement of aromatic and aliphatic imides using a hypervalent iodine(III) reagent generated in situ from PhI, m-CPBA, and TsOH·H2O proceeded in the presence of a base in alcohol to provide anthranilic acid derivatives and amino acid derivatives in high yields, respectively. This reaction proceeds through a tandem reaction via alcoholysis followed by a Hofmann rearrangement promoted by the formation of an imide-λ3-iodane intermediate.