135782-20-6

Basic information

• Product Name: 4-CBZ-2-HYDROXYMETHYLMORPHOLINE
• Synonyms: 4-CBZ-2-HYDROXYMETHYLMORPHOLINE;Benzyl 2-(hydroxyMethyl)Morpholine-4-carboxylate
• CAS NO: 135782-20-6
• Molecular Formula: C₁₃H₁₇NO₄
• Molecular Weight: 251.28
• Product Categories: pharmacetical
• Mol File: 135782-20-6.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 413°Cat760mmHg
• Flash Point: 203.6°C
• Appearance: /
• Density: 1.223g/cm³
• Vapor Pressure: 1.46E-07mmHg at 25°C
• Refractive Index: 1.548
• PKA: 14.36±0.10(Predicted)
• CAS DataBase Reference: 4-CBZ-2-HYDROXYMETHYLMORPHOLINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-CBZ-2-HYDROXYMETHYLMORPHOLINE(135782-20-6)
• EPA Substance Registry System: 4-CBZ-2-HYDROXYMETHYLMORPHOLINE(135782-20-6)

Safety Data

• Hazardous Substances Data: 135782-20-6(Hazardous Substances Data)

Usage

General Description

4-CBZ-2-HYDROXYMETHYLMORPHOLINE, also known as carbobenzoxy-2-hydroxymethylmorpholine, is a chemical compound used in the synthesis of pharmaceuticals and other organic compounds. It is a derivative of morpholine and has a carbobenzoxy group attached to the hydroxymethyl moiety. 4-CBZ-2-HYDROXYMETHYLMORPHOLINE is a versatile intermediate in organic synthesis and is often used as a protecting group for amino alcohols and amines. It is also used in the synthesis of heterocyclic compounds and in the preparation of various pharmaceuticals. 4-CBZ-2-HYDROXYMETHYLMORPHOLINE is known for its ability to selectively protect the hydroxyl group in the presence of other functional groups and is widely used in the pharmaceutical industry for the synthesis of therapeutic agents.

InChI:InChI=1/C13H17NO4/c15-9-12-8-14(6-7-17-12)13(16)18-10-11-4-2-1-3-5-11/h1-5,12,15H,6-10H2

Upstream product

• 501-53-1 benzyl chloroformate 
• 103003-01-6 morpholin-2-ylmethanol 
• 40987-24-4 R,S-2-hydroxymethyl-4-benzylmorpholine 

Downstream Products

• 135782-22-8 Morpholine-2,4-dicarboxylic acid 4-benzyl ester 2-methyl ester 
• 135782-19-3 (RS)-2-(methoxycarbonyl)morpholine 
• 317829-97-3 benzyl 2-formylmorpholine-4-carboxylate 
• 1881275-65-5 2-aminomethyl-4-benzyloxycarbonyl-morpholine 

Relevant articles and documents

HETEROCYCLIC SUBSTITUTED UREAS, FOR USE AGAINST CANCER

The application relates to heterocyclic urea derivatives and their use in the treatment and prophylaxis of cancer, and to compositions containing said derivatives and processes for their preparation.

Src kinase inhibitor compounds

Pyrimidine compounds (Formula I), or their pharmaceutically acceptable salts, hydrates, solvates, crystal forms and individual diastereomers, and pharmaceutical compositions including the same, which are inhibitors of tyrosine kinase enzymes, and as such are useful in the prophylaxis and treatment of protein tyrosine kinase-associated disorders, such as immune diseases, hyperproliferative disorders and other diseases in which inappropriate protein kinase action is believed to play a role, such as cancer, angiogensis, atheroscelerosis, graft rejection, rheumatoid arthritis and psoriasis.

The synthesis of 2-morpholine carboxylic acid derivatives and their elaboration to 1-aza-4-oxabicyclo[3.3.1]nonan-6-one

Two syntheses of novel 2-morpholine carboxylic acid derivatives are described. The esters were converted into 1-aza-4-oxabicyclo[3.3.1]nonan-6-one, the first example of this ring system, which was further elaborated to the ortho-methoxy benzamide derivative (2).