135969-62-9

Basic information

• Product Name: (3aR,6aS)-3,3a,4,5,6,6a-hexahydrocyclopenta[d]oxazol-2-one
• Synonyms: (3aR,6aS)-3,3a,4,5,6,6a-hexahydrocyclopenta[d]oxazol-2-one
• CAS NO: 135969-62-9
• Molecular Weight: 127.143
• Mol File: 135969-62-9.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: (3aR,6aS)-3,3a,4,5,6,6a-hexahydrocyclopenta[d]oxazol-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: (3aR,6aS)-3,3a,4,5,6,6a-hexahydrocyclopenta[d]oxazol-2-one(135969-62-9)
• EPA Substance Registry System: (3aR,6aS)-3,3a,4,5,6,6a-hexahydrocyclopenta[d]oxazol-2-one(135969-62-9)

Safety Data

• Hazardous Substances Data: 135969-62-9(Hazardous Substances Data)

Upstream product

• 32315-10-9 bis(trichloromethyl) carbonate 
• 225791-13-9 (1S,2R)-2-aminocyclopentanol hydrochloride salt 
• 144989-61-7 benzyl (+/-)-trans-(2-hydroxycyclopentyl)carbamate 
• 117416-51-0 3-benzylhexahydro-2H-cyclopenta[d]oxazol-2-one 
• 142-29-0 cyclopentene 
• 51-79-6 urethane 
• 40481-98-9 (1RS,2SR)-2-hydroxy-1-cyclopentanecarboxamide 
• 28435-62-3 (+/-)-trans-2-bromocyclopentanol 
• 117416-45-2 Benzyl-carbamic acid (1S,2S)-2-bromo-cyclopentyl ester 
• 33092-86-3 trans-2-aminocyclopentanol 
• 96-41-3 Cyclopentanol 
• 50715-28-1 cyclopentyl chloroformate 

Downstream Products

• 221152-96-1 benzyl (1S,2R)-N-(2-hydroxycyclopentyl)carbamate 
• 144989-63-9 2-dimethylamino-3a,4,5,6-tetrahydrocyclopentoxazole 
• 144989-62-8 (3aR,6aS)-2-Ethoxy-4,5,6,6a-tetrahydro-3aH-cyclopentaoxazole 
• 135969-66-3 (1S,2R)-2-N-methylaminocyclopentan-1-ol 
• 135969-63-0 (1S,2R)-cis-2-aminocyclopentanol 

Relevant articles and documents

Enzymatic dynamic kinetic resolution of (±)-cis-N-(Alkoxycarbonyl) cyclopentane-1,2-diamines based on spontaneous racemization

Lipase B from Candida antarctica is an excellent catalyst for the enantioselective acetylation of different (±)-cis-N-(alkoxycarbonyl) cyclopentane-1,2-diamines. Depending on the alkoxycarbonyl group, a simple kinetic resolution (Boc-derivative) or an interesting dynamic kinetic resolution (DKR with Cbz-, Alloc, and ethoxycarbonyl derivatives) has been developed. Racemization for the DKR occurred due to the N,N′ intramolecular migration of the alkoxycarbonyl group.

6,7-DIHYDRO-4H-PYRAZOLO[1,5-A]PYRAZINE COMPOUNDS FOR THE TREATMENT OF INFECTIOUS DISEASES

The present invention relates to compounds of the formula (I) or pharmaceutically acceptable salts, enantiomer or diastereomer thereof, wherein R1 to R4 are as described above. The compounds may be useful for the treatment or prophylaxis of hepatitis B virus infection.

A facile synthesis of 2-oxazolidinones via Hofmann rearrangement mediated by bis(trifluoroacetoxy)iodobenzene

A mild and efficient synthesis of 2-oxazolidinones from β-hydroxypropionamides via Hofmann rearrangement was achieved in 96% to quantitative yield using bis(trifluoroacetoxy)iodobenzene (BTI) in acetonitrile. The method should be useful in both solution- and solid-phase construction of 2-oxazolidinone libraries.