1360180-48-8

Basic information

• Product Name: N-((1-(2-oxo-2-(3-phenoxyphenylamino)ethyl)-1H-1,2,3-triazol-4-yl)methyl)-2-(3-oxobenzo[d]isothiazol-2(3H)-yl)acetamide
• Synonyms: N-((1-(2-oxo-2-(3-phenoxyphenylamino)ethyl)-1H-1,2,3-triazol-4-yl)methyl)-2-(3-oxobenzo[d]isothiazol-2(3H)-yl)acetamide
• CAS NO: 1360180-48-8
• Molecular Weight: 514.564
• Mol File: 1360180-48-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-((1-(2-oxo-2-(3-phenoxyphenylamino)ethyl)-1H-1,2,3-triazol-4-yl)methyl)-2-(3-oxobenzo[d]isothiazol-2(3H)-yl)acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-((1-(2-oxo-2-(3-phenoxyphenylamino)ethyl)-1H-1,2,3-triazol-4-yl)methyl)-2-(3-oxobenzo[d]isothiazol-2(3H)-yl)acetamide(1360180-48-8)
• EPA Substance Registry System: N-((1-(2-oxo-2-(3-phenoxyphenylamino)ethyl)-1H-1,2,3-triazol-4-yl)methyl)-2-(3-oxobenzo[d]isothiazol-2(3H)-yl)acetamide(1360180-48-8)

Safety Data

• Hazardous Substances Data: 1360180-48-8(Hazardous Substances Data)

Upstream product

• 3586-12-7 3-phenoxyaniline 
• 82152-06-5 2-(3-Oxo-3h-benzo[d]isothiazol-2-yl)-acetic acid 
• 92290-71-6 chloro-acetic acid-(3-phenoxy-anilide) 
• 1360180-34-2 2-azido-N-(3-phenoxyphenyl)acetamide 
• 1360180-32-0 2-(3-oxobenzo[d]isothiazol-2(3H)-yl)-N-(prop-2-ynyl)acetamide 

Relevant articles and documents

Inhibition of dengue virus and west Nile virus proteases by click chemistry-derived benz[d]isothiazol-3(2H)-one derivatives

Two click chemistry-derived focused libraries based on the benz[d]isothiazol-3(2H)-one scaffold were synthesized and screened against Dengue virus and West Nile virus NS2B-NS3 proteases. Several compounds (4l, 7j-n) displayed noteworthy inhibitory activity toward Dengue virus NS2B-NS3 protease in the absence and presence of added detergent. These compounds could potentially serve as a launching pad for a hit-to-lead optimization campaign.