136083-74-4

Basic information

• Product Name: 2-(9H-fluoren-9-ylmethoxycarbonylamino)pentanedioic acid
• CAS NO: 136083-74-4
• Molecular Weight: 369.374
• Mol File: 136083-74-4.mol
• Article Data: 14

Chemical Properties

• CAS DataBase Reference: 2-(9H-fluoren-9-ylmethoxycarbonylamino)pentanedioic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(9H-fluoren-9-ylmethoxycarbonylamino)pentanedioic acid(136083-74-4)
• EPA Substance Registry System: 2-(9H-fluoren-9-ylmethoxycarbonylamino)pentanedioic acid(136083-74-4)

Safety Data

• Hazardous Substances Data: 136083-74-4(Hazardous Substances Data)

Upstream product

• 71989-18-9 Fmoc-Glu(OtBu)-OH 
• 56-86-0 L-glutamic acid 
• 1131148-55-4 1-[(9-fluorenylmethyloxycarbonyl)]benzotriazole 
• 28920-43-6 (fluorenylmethoxy)carbonyl chloride 
• 84793-07-7 Fmoc-Glu-OtBu 
• 82911-69-1 N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide 
• 84418-43-9 9-fluorenylmethyl carbamate 
• 1481642-14-1 (S)-4-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-5-methoxy-5-oxopentanoic acid 

Downstream Products

• 906374-16-1 C₅₉H₉₄N₁₆O₁₆ 

Relevant articles and documents

SUPRAMOLECULAR GEL SUPPORTED ON OPEN-CELL POLYMER FOAM

The present invention relates to a polymer foam, said polymer foam comprising pores forming an open-cell polymer foam, said polymer foam comprising a supramolecular gel inside pores, and said polymer foam comprising at least one enzyme. The present invention relates to a supramolecular gel; its preparation and its applications, notably in chemical synthesis and kinetic resolution, in particular of organic compounds. The present invention also relates to flow chemistry.

Supported Catalytically Active Supramolecular Hydrogels for Continuous Flow Chemistry

Inspired by biology, one current goal in supramolecular chemistry is to control the emergence of new functionalities arising from the self-assembly of molecules. In particular, some peptides can self-assemble and generate exceptionally catalytically active fibrous networks able to underpin hydrogels. Unfortunately, the mechanical fragility of these materials is incompatible with process developments, relaying this exciting field to academic curiosity. Here, we show that this drawback can be circumvented by enzyme-assisted self-assembly of peptides initiated at the walls of a supporting porous material. We applied this strategy to grow an esterase-like catalytically active supramolecular hydrogel (CASH) in an open-cell polymer foam, filling the whole interior space. Our supported CASH material is highly efficient towards inactivated esters and enables the kinetic resolution of racemates. This hybrid material is robust enough to be used in continuous flow reactors, and is reusable and stable over months.

LIGANDS FOR ENHANCED IMAGING AND DRUG DELIVERY TO NEUROBLASTOMA CELLS

The present invention concerns aminobenzylguanidine derivative ligands specifically targeting neuroblastoma cells with an improved cellular uptake. The improved cellular uptake provides for the therapeutic and diagnostic use of the ligands in neuroblastoma-related diseases.