1365958-43-5

Basic information

• Product Name: 3-(2-(benzyloxy)-6-(3-(benzyloxy)phenyl)naphthalen-1-yl)aniline
• Synonyms: 3-(2-(benzyloxy)-6-(3-(benzyloxy)phenyl)naphthalen-1-yl)aniline
• CAS NO: 1365958-43-5
• Molecular Weight: 507.632
• Mol File: 1365958-43-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-(2-(benzyloxy)-6-(3-(benzyloxy)phenyl)naphthalen-1-yl)aniline(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(2-(benzyloxy)-6-(3-(benzyloxy)phenyl)naphthalen-1-yl)aniline(1365958-43-5)
• EPA Substance Registry System: 3-(2-(benzyloxy)-6-(3-(benzyloxy)phenyl)naphthalen-1-yl)aniline(1365958-43-5)

Safety Data

• Hazardous Substances Data: 1365958-43-5(Hazardous Substances Data)

Upstream product

• 135-19-3 β-naphthol 
• 127399-79-5 2-(benzyloxy)-1,6-dibromonaphthalene 
• 16239-18-2 1,6-dibromo-2-naphthol 
• 1365958-40-2 2-(benzyloxy)-6-(3-(benzyloxy)phenyl)-1-bromonaphthalene 
• 30418-59-8 3-Aminophenylboronic acid 

Downstream Products

• 1365958-92-4 N-(3-(2-(benzyloxy)-6-(3-(benzyloxy)phenyl)naphthalen-1-yl)phenyl)-2-methylbenzenesulfonamide 
• 1365958-75-3 N-(3-(2-(benzyloxy)-6-(3-(benzyloxy)phenyl)naphthalen-1-yl)phenyl)-4-cyanobenzenesulfonamide 
• 1365958-99-1 N-(4-(N-(3-(2-(benzyloxy)-6-(3-(benzyloxy)phenyl)naphthalen-1-yl)phenyl)sulfamoyl)phenyl)acetamide 
• 1365958-67-3 N-(3-(2-(benzyloxy)-6-(3-(benzyloxy)phenyl)naphthalen-1-yl)phenyl)-3-nitrobenzenesulfonamide 
• 1365958-97-9 N-(3-(2-(benzyloxy)-6-(3-(benzyloxy)phenyl)naphthalen-1-yl)phenyl)-4-methylbenzenesulfonamide 
• 1365958-61-7 N-(3-(2-(benzyloxy)-6-(3-(benzyloxy)phenyl)naphthalen-1-yl)phenyl)-3-benzenesulfonamide 
• 1365958-64-0 N-(3-(2-(benzyloxy)-6-(3-(benzyloxy)phenyl)naphthalen-1-yl)phenyl)-2-nitrobenzenesulfonamide 
• 1365958-73-1 C₄₃H₃₂N₂O₄S 
• 1365958-70-8 N-(3-(2-(benzyloxy)-6-(3-(benzyloxy)phenyl)naphthalen-1-yl)phenyl)-2,4-dinitrobenzenesulfonamide 
• 1365958-78-6 N-(3-(2-(benzyloxy)-6-(3-(benzyloxy)phenyl)naphthalen-1-yl)phenyl)-2-fluorobenzenesulfonamide 
• 1365958-83-3 N-(3-(2-(benzyloxy)-6-(3-(benzyloxy)phenyl)naphthalen-1-yl)phenyl)-4-fluorobenzenesulfonamide 
• 1365958-81-1 N-(3-(2-(benzyloxy)-6-(3-(benzyloxy)phenyl)naphthalen-1-yl)phenyl)-3-fluorobenzenesulfonamide 
• 1365958-95-7 N-(3-(2-(benzyloxy)-6-(3-(benzyloxy)phenyl)naphthalen-1-yl)phenyl)-3-methylbenzenesulfonamide 
• 1365959-02-9 N-(3-(2-(benzyloxy)-6-(3-(benzyloxy)phenyl)naphthalen-1-yl)phenyl)-2,2,2-trifluoroethanesulfonamide 

Relevant articles and documents

Lead optimization of 17β-HSD1 inhibitors of the (hydroxyphenyl) naphthol sulfonamide type for the treatment of endometriosis

The reduction of estrone to estradiol, the most potent estrogen in human, is catalyzed by 17β-hydroxysteroid dehydrogenase type 1 (17β-HSD1). A promising approach for the treatment of estrogen-dependent diseases is the reduction of intracellular estradiol formation by inhibition of 17β-HSD1. For the species-specific optimization of the (hydroxyphenyl)naphthols, a combinatorial approach was applied and enhanced by a focused synthesis that resulted in the aromatic-substituted (hydroxyphenyl)naphthol sulfonamides. Rigidification of 12 led to the 4-indolylsulfonamide 30, which is a highly active and selective human 17β-HSD1 inhibitor, as well as a highly potent and selective inhibitor of 17β-HSD1 from Callithrix jacchus. It shows no affinity to the estrogen receptors I?± and β and good intracellular activity (T47D). Thus, compound 30 shows good properties for further ADMET studies and might be a candidate for the in vivo proof of concept in C. jacchus.