1367728-72-0Relevant articles and documents
Three component Kabachnik-Fields condensation leading to substituted aminomethane-P-hydroxymethylphosphonic acids as atool for screening of bacterial urease inhibitors
Vassiliou, Stamatia,Grabowiecka, Agnieszka,Kosikowska, Paulina,Berlicki, Lukasz
experimental part, p. 33 - 43 (2012/03/08)
Condensation of hydroxyalkane-H-phosphinic acids, formaldehyde and secondary amines has given entry to the synthesis of variously substituted aminomethane-P-hydroxymethylphosphinic acids. The proposed strategy allowed to perform a feasible synthesis of several molecules with designed biological activity towards bacterial urease - an enzyme which is a medicinally relevant molecular target. The inhibitory potency of compounds was validated using enzyme purified from Bacillus pasteurii. ARKAT-USA, Inc.
