52705-43-8

Basic information

• Product Name: alpha-hydroxybenzylphosphinic acid
• Synonyms: alpha-hydroxybenzylphosphinic acid;(α-Hydroxybenzyl)phosphinic acid;α-Hydroxybenzylphosphinic acid;a-Hydroxybenzylphosphinic Acid;DPQYARCVTAMMLE-UHFFFAOYSA-N
• CAS NO: 52705-43-8
• Molecular Formula: C₇H₉O₃P
• Molecular Weight: 172.118321
• EINECS: 258-116-4
• Mol File: 52705-43-8.mol
• Article Data: 6

Chemical Properties

• Melting Point: 110°
• Boiling Point: 369.1°Cat760mmHg
• Flash Point: 177°C
• Appearance: /
• Density: g/cm³
• CAS DataBase Reference: alpha-hydroxybenzylphosphinic acid(CAS DataBase Reference)
• NIST Chemistry Reference: alpha-hydroxybenzylphosphinic acid(52705-43-8)
• EPA Substance Registry System: alpha-hydroxybenzylphosphinic acid(52705-43-8)

Safety Data

• Hazardous Substances Data: 52705-43-8(Hazardous Substances Data)

Upstream product

• 100-52-7 benzaldehyde 
• 760133-36-6 1-hydroxy-1-phenylmethyl-1,1-bis(H-phosphinic acid) 
• 6303-21-5 hypophosphorous acid 
• 56547-85-4 O-trimethylsilyl [phenyl(trimethylsiloxy)methyl]phosphonite 

Downstream Products

• 6881-57-8 benzylphosphonic acid 
• 100-52-7 benzaldehyde 
• 913943-35-8 N,N-dimethylaminomethane-P-(1-hydroxyphenylmethyl)phosphinic acid 
• 1367728-72-0 N-benzyl-N-methylaminomethane-P-(1-hydroxyphenylmethyl)phosphinic acid 
• 1013036-08-2 C₉H₁₃O₄P 
• 1013036-09-3 C₁₁H₁₅O₄P 
• 102-07-8 bis(diphenyl)urea 
• 1127-41-9 (α-hydroxybenzyl)phosphonic acid 

Relevant articles and documents

Novel method for the synthesis of α-amino-α- hydroxyalkylphosphinic acids and bis(α-aminoalkyl)phosphinic acids: Nuclephilic addition of α-hydroxy-H-phosphinic acids to diimines

We report here a novel and simple method for the synthesis of α-amino-α-hydroxyalkylphosphinic acids in good yields in two simple steps without any protection-deprotection steps. We have developed an efficient method for the synthesis of α-amino-α-hydroxyalkylphosphinic acids via the reaction of easily available α-hydroxyalkylphosphinic acids with diimines. Treatment of α-hydroxyalkylphosphinic acids with diimines in the presence of trimethylsilyl chloride (TMSCl) gives α-amino-α- hydroxyalkylphosphinic acids in good yields. The reaction gave a mixture of two diastereomeric forms of α-amino-α-hydroxyalkylphosphinic acids. The difference in solubility in organic solvents allowed us to readily separate the diastereoisomers. Georg Thieme Verlag Stuttgart · New York.

Three component Kabachnik-Fields condensation leading to substituted aminomethane-P-hydroxymethylphosphonic acids as atool for screening of bacterial urease inhibitors

Condensation of hydroxyalkane-H-phosphinic acids, formaldehyde and secondary amines has given entry to the synthesis of variously substituted aminomethane-P-hydroxymethylphosphinic acids. The proposed strategy allowed to perform a feasible synthesis of several molecules with designed biological activity towards bacterial urease - an enzyme which is a medicinally relevant molecular target. The inhibitory potency of compounds was validated using enzyme purified from Bacillus pasteurii. ARKAT-USA, Inc.

Asymmetrically substituted phosphinic acids

The invention relates to asymmetrically substituted phosphinic acids of the formula (I) [in-line-formulae]R1R2C(OH)—P(═O)(OX)—C(OH)R3R4 ??(I)[/in-line-formulae] in which X is hydrogenR1, R2, R3, and R4 are identical or different and are hydrogen, alkyl, alkenyl, alkynyl, aralkyl, aryl and/or alkaryl,with the proviso that the respective R1R2C(OH)— and —C(OH)R3R4 groups are always different, to a process for their preparation, and to their use.