137-88-2 Usage
Description
Amprolium is a thiamine analog and antiprotozoal agent that interferes with thiamine metabolism and inhibits carbohydrate synthesis. It competitively inhibits thiamine uptake by E. tenella schizonts and by chick host intestinal cells (Kis = 7.6 and 326 μM, respectively). It also inhibits hexose formation and pentose utilization ex vivo in isolated lysed rat erythrocytes and in liver, kidney, heart, and intestinal tissue homogenates following dietary administration. Amprolium (1,000 ppm in feed) inhibits oocyst output and sporulation of Eimeria maxima, E. brunetti, and E. acervulina in infected chicks. It also decreases lesion and oocyst scores and mortality of E. tenella-infected chicks following dietary administration of a 125 ppm dose. Amprolium (100 μM) induces apoptosis in PC12 rat adrenal cells and increases the level of cleaved caspase-3. Formulations containing amprolium have been used as coccidiostats in poultry processing.
Chemical Properties
Crystalline powder
Uses
Different sources of media describe the Uses of 137-88-2 differently. You can refer to the following data:
1. Coccidiostatic;Thiamine transport inhibitor
2. 1-(4-Amino-2-n-propyl-5-pyrimidinylmethyl)-2-methylpyridinium Chloride is an antiparasytic drug used in the veterinary industry. In addition the compound shows anticoccidial activity.
3. Thiamine analog coccidiostat.
Veterinary Drugs and Treatments
Amprolium has good activity against Eimeria tenella and E. acervulina
in poultry and can be used as a therapeutic agent for these
organisms. It only has marginal activity or weak activity
against E. maxima, E. mivati, E. necatrix, or E. brunetti. It is often used in
combination with other agents (e.g., ethopabate) to improve control
against those organisms.
In cattle, amprolium has approval for the treatment and prevention
of E. bovis and E. zurnii in cattle and calves.
Amprolium has been used in dogs, swine, sheep, and goats for the
control of coccidiosis, although there are no approved products in
the USA for these species.
Check Digit Verification of cas no
The CAS Registry Mumber 137-88-2 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 1,3 and 7 respectively; the second part has 2 digits, 8 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 137-88:
(5*1)+(4*3)+(3*7)+(2*8)+(1*8)=62
62 % 10 = 2
So 137-88-2 is a valid CAS Registry Number.
InChI:InChI=1/C14H19N4.ClH/c1-3-6-13-16-9-12(14(15)17-13)10-18-8-5-4-7-11(18)2;/h4-5,7-9H,3,6,10H2,1-2H3,(H2,15,16,17);1H/q+1;