137-97-3 Usage
Description
1,3-Di(O-tolyl)thiourea is an organic compound with the chemical formula C15H14N2S. It is characterized by its colorless, crystalline leaflets and a pungent odor. 1,3-DI(O-TOLYL)THIOUREA is not hygroscopic, meaning it does not absorb moisture from the environment, and is soluble in alcohol, ether, and benzene, but insoluble in water. Its chemical structure and properties make it suitable for various applications across different industries.
Uses
Used in Pharmaceutical Industry:
1,3-Di(O-tolyl)thiourea is used as an inhibitor of secreted aspartic protease SAP2 for the treatment of drug-resistant Candida albicans infections. Candida albicans is a common yeast that can cause infections in humans, and drug resistance has become a significant challenge in treating these infections. The compound's ability to inhibit SAP2 makes it a valuable asset in the development of new therapeutic strategies against drug-resistant Candida albicans.
Used in Metal Industry:
1,3-Di(O-tolyl)thiourea is also used as a metal-pickling inhibitor. In the metal industry, pickling is the process of removing rust, scale, and other impurities from the surface of metals, such as steel, to prepare them for further processing or fabrication. The use of 1,3-di(O-tolyl)thiourea as an inhibitor helps to prevent the formation of excessive hydrogen gas during the pickling process, which can be dangerous and lead to safety hazards. By acting as an inhibitor, it ensures a safer and more controlled pickling process, improving the efficiency and safety of metal production.
Hazard
Toxic by ingestion.
Safety Profile
Poison by intraperitoneal
route. Moderately toxic by ingestion. When heated
to decomposition it emits very toxic fumes of NOx
and SOx
Check Digit Verification of cas no
The CAS Registry Mumber 137-97-3 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 1,3 and 7 respectively; the second part has 2 digits, 9 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 137-97:
(5*1)+(4*3)+(3*7)+(2*9)+(1*7)=63
63 % 10 = 3
So 137-97-3 is a valid CAS Registry Number.
InChI:InChI=1/C15H16N2S/c1-11-7-3-5-9-13(11)16-15(18)17-14-10-6-4-8-12(14)2/h3-10H,1-2H3,(H2,16,17,18)
137-97-3Relevant articles and documents
Synthesis method of thiourea
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Paragraph 0020; 0024, (2020/12/08)
The invention relates to a synthesis method of thiourea. A method for generating thiourea from amine and carbon disulfide under the action of tertiary amine alkali is a common synthesis method adoptedin the prior art; and when the method is used for preparing the thiourea, a byproduct, namely hydrogen sulfide is generate, and the hydrogen sulfide needs to be fully absorbed by an alkali absorptionsystem and also reacts with the tertiary amine alkali to generate an amine salt, so a large amount of a tertiary amine alkali catalyst needs to be added in the reaction. In order to solve the above problem, the invention provides the synthesis method for thiourea; and according to the synthesis method, a proper amount of an inorganic base is added into a reaction system, so the inorganic base cantimely react with the byproduct hydrogen sulfide to form an inorganic salt without a subsequent alkali absorption system, the usage amount of the catalyst tertiary amine alkali can be greatly reduced, and the subsequent recovery work of a large amount of the tertiary amine alkali is also reduced.
Novel non-peptidic small molecule inhibitors of secreted aspartic protease 2 (SAP2) for the treatment of resistant fungal infections
Dong, Guoqiang,Liu, Yang,Wu, Ying,Tu, Jie,Chen, Shuqiang,Liu, Na,Sheng, Chunquan
supporting information, p. 13535 - 13538 (2019/01/05)
Targeting secreted aspartic protease 2 (SAP2), a kind of virulence factor, represents a new strategy for antifungal drug discovery. In this report, the first-generation of small molecule SAP2 inhibitors was rationally designed and optimized using a structure-based approach. In particular, inhibitor 23h was highly potent and selective and showed good antifungal potency for the treatment of resistant Candida albicans infections.
