137132-12-8

Basic information

• Product Name: Butanoic acid, 3-aMino-, Methyl ester, hydrochloride
• Synonyms: Butanoic acid, 3-aMino-, Methyl ester, hydrochloride;Methyl 3-aMinobutanoate hydrochloride;3-Amino-butanoic acid methyl ester HCl;methyl 3-aminobutanoate HCl;3-amino-Butanoic acid methyl ester hydrochloride
• CAS NO: 137132-12-8
• Molecular Formula: C₅H₁₂NO₂*Cl
• Molecular Weight: 153.60728
• Mol File: 137132-12-8.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: Butanoic acid, 3-aMino-, Methyl ester, hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: Butanoic acid, 3-aMino-, Methyl ester, hydrochloride(137132-12-8)
• EPA Substance Registry System: Butanoic acid, 3-aMino-, Methyl ester, hydrochloride(137132-12-8)

Safety Data

• Hazardous Substances Data: 137132-12-8(Hazardous Substances Data)

Usage

General Description

Butanoic acid, 3-amino-, methyl ester, hydrochloride is a chemical compound that contains the ester of 3-amino butanoic acid, also known as gamma-aminobutyric acid (GABA), with methyl and hydrochloride groups. GABA is a naturally occurring neurotransmitter in the brain that promotes relaxation and inhibits nerve activity. The esterification of GABA with methyl group enables better absorption and transport across the blood-brain barrier. The addition of the hydrochloride group can increase the stability and solubility of the compound, making it more suitable for pharmaceutical applications. Butanoic acid, 3-amino-, methyl ester, hydrochloride has potential uses in the pharmaceutical industry for the treatment of neurological disorders, anxiety, and insomnia.

Upstream product

• 67-56-1 methanol 
• 2835-82-7 3-aminobutyric acid 
• 21731-17-9 methyl 3-aminocrotonate 

Downstream Products

• 3833-52-1 3-aminobutyric hydroxamic acid 
• 1448260-71-6 methyl 3-(2,4-dinitrophenylsulfonylamino)butanoate 
• 1219839-49-2 C₉H₁₅NO₅ 
• 139243-55-3 (S)-3-aminobutanoic acid methyl ester hydrochloride 
• 139243-54-2 (R)-3-aminobutanoic acid methyl ester hydrochloride 
• 1219839-36-7 C₁₂H₂₁NO₅ 
• 119645-11-3 methyl 3-(N,N-dibenzylamino)butanoate 
• 83468-99-9 methyl β-benzyloxycarbonylaminobutyryl-β-aminobutyrate 
• 137132-14-0 3-N-amino- butanoic acid methyl ester 

Relevant articles and documents

3d-4f Metallacrown complexes with a new sandwich core: Synthesis, structures and single molecule magnet behavior

Two heterometallic metallacrown complexes, [Er{Cu4(butyrat)4}2]·Cl3·MeOH·26H2O (1) and [Yb{Cu4(butyrat)4}2]·Cl3·MeOH·26H2O (2) (H2butyrat = 3-aminobutyric hydroxamic acid), have been reported. X-ray crystallographic analysis reveals that the two complexes displayed nested-sandwich configurations with two 12-MC-4 metallacrown units capping LnIII in the centre. Magnetic studies revealed that 1-2 undergo antiferromagnetic coupling interaction. Magnetic measurements show that complex 2 displays frequency-dependent signals at a dc field of 1000 Oe, indicating field-induced single-molecule magnet behavior.

Synthesis and physicochemical characterization of new C-functionalized derivatives of the gadolinium(III) complex with 3,6,10-tris(carboxymethyl)-3,6, 10-triazadodecanedioic acid (H5ttda) exhibiting fast water exchange - Potential paramagnetic reporters for molecular imaging

To confirm the observation that [Gd(ttda)] derivatives have a significantly shorter residence time τM of the coordinated H2O molecule than [Gd(dtpa)], four new C-functionalized [Gd(ttda)] complexes, [Gd(4-Me-ttda)] (1), [Gd(4-Ph-ttda)] (2), [Gd(9-Me-ttda)] (3), and [Gd(9-Ph-ttda)] (4), were prepared and characterized (H5ttda = 3,6,10-tris(carboxymethyl)-3,6,10-triazadodecanedioic acid; H5dtpa = 3,6,9-tris(carboxymethyl)-3,6,9-triazaundecanedioic acid). The temperature dependence of the proton relaxivity for these complexes at 0.47 T and of the 17O transverse relaxation rate of H217O at 7.05 T confirm that the proton relaxivity is not limited by the H 2O-exchange rate. The residence time of the H2O molecules in the first coordination sphere of the gadolinium complexes at 310 K, as calculated from 17O-NMR data, is 13, 43, 2.9, and 56 ns for 1, 2, 3, and 4, respectively. At 310 K, the longitudinal relaxivity of 2 is higher than for the parent compound [Gd(ttda)] and the other complexes of the series. The stability of the new compounds was studied by transmetallation with Zn 2+ ions. All the new complexes are more stable than the parent compound [Gd(ttda)].

Method of producing 3-aminoalkanoic acid esters

The invention relates to a method of producing 3-aminoalkanoic acid esters of the general formula (I), wherein R represents C1-6 alkyl, and R1 represents hydrogen, C1-6 alkyl or phenyl, or the salts thereof, by catalytically hydrating the corresponding 3-amino-2-alkenoic acid esters in the presence of a strong acid.