1373037-72-9Relevant articles and documents
Asymmetric radical addition of TEMPO to titanium enolates
Mabe, Phillip J.,Zakarian, Armen
supporting information, p. 516 - 519 (2014/04/03)
A mild method for a-hydroxylation of N-acyl oxazolidinones by asymmetric radical addition of the 2,2,6,6-tetramethylpiperidine N-oxy (TEMPO) radical to titanium enolates was developed. The high diastereoselectivity and broad scope of the reaction show synthetic utility for the a-hydroxylation of substrates that are not tolerant to strongly basic conditions.