1375180-02-1Relevant articles and documents
The Total Synthesis of Spermine Alkaloid Kukoamine Bimesylate
Dong, Kai
, p. 2669 - 2672 (2018)
The first total synthesis of kukoamine B bimesylate was completed from 1,4-diaminobutane dihydrochloride in 12 steps with a 11.4% overall yield, and all the steps could be carried out at a kilogram scale. The cyano groups were used as the precursor of amino groups to avoid the competitive reaction delicately. The aza-Michael addition reaction, amidation and hydrogenation of the cyano group sequence was streamlined as a general approach towards the synthesis of polyamine structures.
PHOTO-CLEAVABLE PRIMER COMPOSITIONS AND METHODS OF USE
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Paragraph 0080; 0081, (2017/08/24)
In one embodiment, the present application discloses a photo-cleavable surface binding compound of the Formula I and Formula II: wherein the variables EG, EG1, SP1, SP2, SP3, Ar and BG are as defined herein. In another embodiment, the application discloses a method for forming a coating on a surface of a substrate using the surface binding compound.
SALTS OF KUKOAMINE B, PREPARATION METHOD AND USE THEREOF
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Paragraph 0036, (2013/09/26)
Provided are salts of kukoamine B, their preparation method and their use in preventing and treating sepsis diseases.