137618-52-1Relevant articles and documents
MORPHOLINE AND 1,4-OXAZEPANE AMIDES AS SOMATOSTATIN RECEPTOR SUBTYPE 4 (SSTR4) AGONISTS
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Page/Page column 88, (2016/06/06)
The invention relates to morpholine and 1,4-oxazepane amide derivatives of general formula (I), which are agonists of somatostatin receptor subtype 4 (SSTR4), useful for preventing or treating medical disorders related to SSTR4. In addition, the invention
Efficient lipase-catalyzed kinetic resolution of 4-arylmethoxy-3-hydroxybutanenitriles: application to an expedient synthesis of a statin intermediate
Sun, Fenglai,Xu, Gang,Wu, Jianping,Yang, Lirong
, p. 2907 - 2913 (2007/10/03)
The kinetic resolution of 4-arylmethoxy-3-hydroxybutanenitriles was investigated by lipase-catalyzed transesterification in organic solvents. A high enantioselectivity was obtained via reaction with vinyl acetate in a mixed solvent (n-heptane/acetonitrile 1:1), which was catalyzed by the lipase from Artgribacter sp. A better selectivity was demonstrated when the number of substituents on the aryl ring increased. (S)-4-Arylmethoxy-3-hydroxybutanenitriles can be obtained with enantiomeric excesses of up to 98.0% by this method. Furthermore we have developed a novel route to synthesize tert-butyl (S)-6-benzyloxy-5-hydroxy-3-oxohexanoate, a key intermediate for the preparation of HMG-CoA reductase inhibitors (statins).
Nucleophilic Addition to Cyclic 1,2-Sulfites
Carlsen, Per H.,Aase, Kristin J.
, p. 617 - 619 (2007/10/02)
Addition of heteroatom nucleophiles has been shown to attack at either the C5- or the S-atom sites in 4-(benzyloxymethyl)-1,3-dioxa-2-thiolane 2-oxide.No C4-reactivity was observed.The regioselectivity depended on the type of nucleophile.