137628-17-2 Usage
Description
2,3 Dibromo-5-chloro pyridine is an organic compound with the molecular formula C5H3Br2ClN. It is a halogenated pyridine derivative characterized by the presence of two bromine atoms at the 2nd and 3rd positions and a chlorine atom at the 5th position on the pyridine ring. 2,3 DIBROMO-5-CHLORO PYRIDINE is known for its reactivity and is commonly utilized in various chemical reactions and synthesis processes.
Uses
Used in Chemical Synthesis:
2,3 Dibromo-5-chloro pyridine is used as a reactant for regiospecific Grignard reactions with lactones. The presence of multiple halogens on the pyridine ring allows for selective reactions with Grignard reagents, which are organomagnesium compounds. This selective reactivity is valuable in the synthesis of complex organic molecules and pharmaceutical compounds, as it enables chemists to control the position of functional groups within the molecule.
In the pharmaceutical industry, 2,3 Dibromo-5-chloro pyridine can be used as a building block for the development of new drugs, particularly those targeting the central nervous system or exhibiting antimicrobial properties. The compound's unique structure and reactivity make it a versatile starting material for the synthesis of various drug candidates.
Additionally, 2,3 Dibromo-5-chloro pyridine may find applications in the agrochemical industry, where it can be used as a precursor for the synthesis of pesticides or other crop protection agents. The compound's halogenated nature and reactivity with Grignard reagents can be exploited to create new molecules with improved biological activity and selectivity.
Check Digit Verification of cas no
The CAS Registry Mumber 137628-17-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,7,6,2 and 8 respectively; the second part has 2 digits, 1 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 137628-17:
(8*1)+(7*3)+(6*7)+(5*6)+(4*2)+(3*8)+(2*1)+(1*7)=142
142 % 10 = 2
So 137628-17-2 is a valid CAS Registry Number.
InChI:InChI=1/C5H2Br2ClN/c6-4-1-3(8)2-9-5(4)7/h1-2H
137628-17-2Relevant articles and documents
Chiral Hexahalogenated 4,4′-Bipyridines
Mamane,Peluso,Aubert,Cossu,Pale
, p. 4576 - 4587 (2016/07/06)
The preparation of 27 isomers of chiral hexahalogeno-4,4′-bipyridines by means of two complementary methods is described. The first one is convergent and based on the LDA-induced 4,4′-dimerization of trihalopyridines, whereas the second method is divergent and achieved through regioselective halogenation reactions of 4,4′-bipyridine-2,2′-diones. Iodine in 2,2′-positions of the 4,4′-bipyridines was introduced by a copper-catalyzed Finkelstein reaction (Buchwald procedure) performed on 2,2′-dibromo derivatives. Selected compounds of this new family of atropisomeric 4,4′-bipyridines were enantioseparated by high performance liquid chromatography on chiral stationary phases, and the absolute configurations of the separated enantiomers were assigned by using X-ray diffraction analysis. The latter revealed that various halogen bond types are responsible for crystal cohesion.
3-bromo-5-chloro-pyridines used as intermediates in the synthesis of azatetralones
-
, (2008/06/13)
Compounds of the formula STR1 wherein R1 is hydrogen, fluoro, chloro, bromo, nitro, trifluoromethyl, C1 to C4 alkoxy, C1 to C4 alkylthio or C1 to C6 alkyl and R2 is a group of the formula STR2 wherein R3 is hydrogen or C1 to C6 alkyl, R4 is --CH=C2, --CH2 --YR5, or --COR6, R5 is hydrogen or an acid labile alcohol protecting group, Y is oxygen or sulfur, and R6 is --NR7 R8 or --OR9 wherein R7, R8 and R9 are independently selected from hydrogen or C1 to C6 alkyl, or an alkaline or alkaline earth metal salt thereof, which are intermediates in the preparation of hydantoin aldose reductase inhibitors and methods of preparing these intermediates.
6-CHLORO-3,4-DIHYDRO-PYRANO [2,3-B]PYRIDINES HAVING THE R CONFIGURATION
-
, (2008/06/13)
The present invention relates to processes and intermediates for the preparation of spiro-heteroazolones. The latter compounds are useful as aldose reductase inhibitors
