1380298-40-7

Basic information

• Product Name: C₂₂H₃₉NO₆SSi
• Synonyms: C₂₂H₃₉NO₆SSi
• CAS NO: 1380298-40-7
• Molecular Weight: 473.706
• Mol File: 1380298-40-7.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: C₂₂H₃₉NO₆SSi(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₂H₃₉NO₆SSi(1380298-40-7)
• EPA Substance Registry System: C₂₂H₃₉NO₆SSi(1380298-40-7)

Safety Data

• Hazardous Substances Data: 1380298-40-7(Hazardous Substances Data)

Upstream product

• 98-59-9 p-toluenesulfonyl chloride 
• 191655-46-6 tert-butyl (S)-(4-((tert-butyldimethylsilyl)oxy)-1-hydroxybutan-2-yl)carbamate 
• 474023-97-7 (2S)-amino-4-(tert-butyldimethylsilanyloxy)butanoic acid 
• 191655-45-5 (2S)‐2‐{[(tert‐butoxy)carbonyl]amino}‐4‐[(tert‐butyldimethylsilyl)oxy]butanoic acid 

Downstream Products

• 1380243-35-5 (R)-tert-butyl 4-(tert-butyldimethylsilyloxy)-1-(2,4,5-trifluorophenyl)butan-2-ylcarbamate 
• 1048703-14-5 (R)-tert-butyl (4-hydroxy-1-(2,4,5-trifluorophenyl)butan-2-yl)carbamate 
• 486460-00-8 (3R)-3-[(1,1-dimethylethoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoic acid 
• 486460-23-5 (R)-tert-butyl 4-oxo-4-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-1-(2,4,5-trifluorophenyl)butan-2-ylcarbamate 

Relevant articles and documents

INTERMEDIATES OF SITAGLIPTIN AND PREPARATION PROCESS THEREOF

Disclosed are intermediates of Sitagliptin, a preparation process thereof, and a process for synthesizing Sitagliptin using these intermediates. Sitagliptin is synthesized by using chiral amino compounds as a raw material, without having to build a chiral center with a chiral asymmetric catalytic hydrogenation, and high-pressure hydrogenation is avoided.