138163-08-3

Basic information

• Product Name: 4-FORMYL-N-CBZ-PIPERIDINE
• Synonyms: 4-FORMYL-N-CBZ-PIPERIDINE;4-FORMYL-PIPERIDINE-1-CARBOXYLIC ACID BENZYL ESTER;BUTTPARK 92\50-59;BENZYL 4-FORMYLTETRAHYDRO-1(2H)-PYRIDINECARBOXYLATE;N-CBZ-4-PIPERIDINYLCARBOXALDEHYDE;N-CBZ-4-FORMYLPIPERIDINE;Piperidine-4-carboxaldehyde, N-CBZ protected;Benzyl 4-formyltetrahydro-1(2H)-pyridinecarboxylate, 90+%
• CAS NO: 138163-08-3
• Molecular Formula: C₁₄H₁₇NO₃
• Molecular Weight: 247.29
• Product Categories: Carbonyl Compounds;Heterocycles
• Mol File: 138163-08-3.mol
• Article Data: 28

Chemical Properties

• Boiling Point: 384.5 °C at 760 mmHg
• Flash Point: 186.3 °C
• Appearance: /
• Density: 1.221 g/cm³
• Vapor Pressure: 4.07E-06mmHg at 25°C
• Refractive Index: 1.593
• Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
• PKA: -2.18±0.40(Predicted)
• CAS DataBase Reference: 4-FORMYL-N-CBZ-PIPERIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-FORMYL-N-CBZ-PIPERIDINE(138163-08-3)
• EPA Substance Registry System: 4-FORMYL-N-CBZ-PIPERIDINE(138163-08-3)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39-24/25
• Hazardous Substances Data: 138163-08-3(Hazardous Substances Data)

Usage

Description

4-FORMYL-N-CBZ-PIPERIDINE is an organic compound that serves as a crucial intermediate in the synthesis of various pharmaceuticals and bioactive molecules. It is characterized by its unique chemical structure, which includes a formyl group, a carbamate group, and a piperidine ring. 4-FORMYL-N-CBZ-PIPERIDINE is known for its potential applications in the development of novel therapeutic agents.

Uses

Used in Pharmaceutical Industry:
4-FORMYL-N-CBZ-PIPERIDINE is used as a key synthetic building block for the development of pyrimidinyltetrahydropyridoindoles. These molecules have the potential to act as estrogen receptor degrading PROTACs (Proteolysis Targeting Chimeras), which are a new class of therapeutic agents designed to degrade specific proteins within cells. By targeting and degrading estrogen receptors, these PROTACs may offer novel treatment options for various hormone-related disorders and cancers.

InChI:InChI=1/C14H17NO3/c16-10-12-6-8-15(9-7-12)14(17)18-11-13-4-2-1-3-5-13/h1-5,10,12H,6-9,11H2

Upstream product

• 122860-33-7 benzyl 4-(hydroxymethyl)piperidine-N-carboxylate 
• 501-53-1 benzyl chloroformate 
• 79-37-8 oxalyl dichloride 
• 148148-48-5 4-(N-methoxy-N-methyl-carbamoyl)-piperidine-1-carboxylic acid benzyl ester 
• 6457-49-4 4-piperidinemethanol 
• 87413-09-0 Dess-Martin periodane 
• 10314-98-4 1-benzyloxycarbonylpiperidine-4-carboxylic acid 
• 498-94-2 isonipecotic acid 
• 160809-38-1 1-benzyl 4-ethyl piperidine-1,4-dicarboxylate 
• 1126-09-6 4-carbethoxypiperidine 
• 10314-99-5 benzyl 4-(chlorocarbonyl)piperidine-1-carboxylate 
• 138163-07-2 piperidine-1,4-dicarboxylic acid 1-benzyl ester 4-methyl ester 

Downstream Products

• 189333-18-4 3-oxo-9-azaspiro[5.5]undec-4-ene-9-carboxylic acid benzyl ester 
• 1056629-32-3 3-Azaspiro[5.5]undecan-9-one 
• 396073-62-4 4-((E)-5-Methoxycarbonyl-pent-1-enyl)-piperidine-1-carboxylic acid benzyl ester 
• 527693-82-9 3-[N-(benzyloxycarbonylpiperidin-4-yl)]propenoic acid 
• 167484-18-6 benzyl spiro[indoline-3,4’-piperidine]-1‘-carboxylate 
• 209348-85-6 benzyl 5-fluoro-1,2-dihydro-1'H-spiro[indole-3,4'-piperidin]-1'-carboxylate 
• 833491-21-7 3-[N-(benzyloxycarbonyl)piperidin-4-yl]propenoic acid 
• 880271-50-1 benzyl 5-nitro-1,2-dihydro-1'H-spiro[indole-3,4'-piperidine]-1'-carboxylate 
• 618112-62-2 Phenylmethyl 4-(hydroxymethyl)-4-sulfanylpiperidinecarboxylate 
• 189442-56-6 4-[1-hydroxy-5-(2-fluoropyridin-4-yl)-4-(3-trifluoromethylphenyl)-1H-imidazol-2-yl]piperidine-1-carboxylic acid benzyl ester 
• 1075221-27-0 C₂₂H₂₆N₂O₃ 
• 1093956-68-3 Phenylmethyl 6-chloro-1,2-dihydro-1'H-spiro[indole-3,4'-piperidine]-1'-carboxylate 
• 1220250-60-1 C₃₇H₄₁F₃N₂O₄ 
• 1356928-24-9 benzyl 1-ethyl-1,4-dihydrospiro[indazole-5,4'-piperidine]-1'-carboxylate 

Relevant articles and documents

Drastic fluorine effect: Complete reversal of the selectivity in the Au-catalyzed hydroalkoxylation reaction of fluorinated haloalkynes

The gold-catalyzed hydration reaction of haloalkynes is highly regioselective producing 2-halomethylketones as the sole products. Herein, we document a drastic fluorine effect where the reaction of 1-halo-3,3-difluoroalkynes as substrates leads to a complete reversal of selectivity and produces 3,3-difluoroesters as the unique products.

Highly regioselective gold-catalyzed formal hydration of propargylic: Gem -difluorides

Herein, we report a highly regioselective gold-catalyzed formal hydration of propargylic gem-difluorides. Not only does this transformation provide access to versatile fluorinated building blocks that were difficult or hardly possible to access beforehand, but it also represents a rare case of a highly regioselective gold-catalyzed hydroalkoxylation of internal alkynes and puts forward the utility of the difluoromethylene unit as a directing group in catalysis.

SULFONAMIDE RETINOIC ACID RECEPTOR-RELATED ORPHAN RECEPTOR MODULATORS AND USES THEREOF

Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of Retinoic Acid Receptor-Related Orphan Receptor regulated diseases and disorders.