1391090-18-8Relevant articles and documents
α-Amination of keto-nitrones via Multihetero-Cope rearrangement employing an imidoyl chloride reagent
Malinowski, Justin T.,Malow, Ericka J.,Johnson, Jeffrey S.
supporting information; experimental part, p. 7568 - 7570 (2012/10/07)
α-Aminations of ketone-derived nitrones have been developed via [3,3]-rearrangement of the intermediates generated upon condensation with imidoyl chlorides. Careful reagent selection provides synthetically attractive amino protecting groups. The enediamide or α′-carbamoyl enamide products can be hydrolyzed to the desired carbonyl, or exposed to electrophiles for further α-functionalization.