1391601-25-4Relevant articles and documents
Three-component coupling of aldehydes, amines, and alkynes catalyzed by oxidized copper nanoparticles on titania
Albaladejo, Maria Jose,Alonso, Francisco,Moglie, Yanina,Yus, Miguel
experimental part, p. 3093 - 3104 (2012/06/30)
Copper nanoparticles (mainly as Cu2O) on titania have been shown to catalyze the multicomponent synthesis of propargylamines from aldehydes, amines, and alkynes (A3 coupling) effectively at 70 °C under solvent-free conditions. Both aromatic and aliphatic aldehydes and alkynes have been combined with secondary amines to provide a wide range of propargylamines in moderate to excellent yields. Two examples of ketone/amine/alkyne (KA 2) coupling are also included. The catalyst is easy to prepare, reusable at a low copper loading (0.5 mol-%), and exhibits higher catalytic activity than some commercially available copper sources. Some mechanistic aspects of the reaction have also been examined, which have unveiled the participation of copper(I) acetylides in a heterogeneous process. Copyright
