1397525-83-5

Basic information

• Product Name: (5S,6S,9R)-6-(2,3-difluorophenyl)-9-((triisopropylsilyl)oxy)-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-5-ol hydrochloride
• Synonyms: (5S,6S,9R)-6-(2,3-difluorophenyl)-9-((triisopropylsilyl)oxy)-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-5-ol hydrochloride
• CAS NO: 1397525-83-5
• Molecular Weight: 484.102
• Mol File: 1397525-83-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (5S,6S,9R)-6-(2,3-difluorophenyl)-9-((triisopropylsilyl)oxy)-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-5-ol hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: (5S,6S,9R)-6-(2,3-difluorophenyl)-9-((triisopropylsilyl)oxy)-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-5-ol hydrochloride(1397525-83-5)
• EPA Substance Registry System: (5S,6S,9R)-6-(2,3-difluorophenyl)-9-((triisopropylsilyl)oxy)-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-5-ol hydrochloride(1397525-83-5)

Safety Data

• Hazardous Substances Data: 1397525-83-5(Hazardous Substances Data)

Upstream product

• 1190363-44-0 (R)-9-hydroxy-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-5-one hydrochloride 
• 39713-40-1 7,8-dihydro-5H-cyclohepta[b]pyridine-5,9(6H)-dione 
• 1190363-46-2 (6S,9R)-6-(2,3-difluorophenyl)-9-((triisopropylsilyl)oxy)-6,7,8,9-tetrahydro-5Hcyclohepta[b]pyridin-5-one 
• 1190363-45-1 (R)-9-((triisopropylsilyl)oxy)-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-5-one 
• 39713-36-5 dimethyl 5,9-dihydroxy-7H-cyclohepta[b]pyridine-6,8-dicarboxylate 
• 1354640-52-0 (9R)-6-(2,3-difluorophenyl)-9-((triisopropylsilyl)oxy)-6,7,8,9-tetrahydro-5Hcyclohepta[b]pyridin-5-one 
• 605-38-9 dimethyl 2,3-pyridinedicarboxylate 

Downstream Products

• 1190363-49-5 (6R,9R)-6-(2,3-difluorophenyl)-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-9-ol 
• 1190363-03-1 BMS-846372 
• 1190363-51-9 (5S,6S,9R)-6-(2,3-difluorophenyl)-9-(triisopropylsilyloxy)-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-5-yl methanesulfonate 

Relevant articles and documents

Efficient and scalable enantioselective synthesis of a CGRP antagonist

An enantioselective synthesis of the CGRP antagonist BMS-846372, amenable to large scale preparation, is presented. This new synthesis showcases a chemo- and enantioselective reduction of a cyclohepta[b]pyridine-5,9-dione as well as a Pd-catalyzed alpha-arylation reaction to form the key carbon-carbon bond and set the absolute and relative stereochemistry.