1403480-28-3

Basic information

• Product Name: N-((2R,3R)-3-((tert-butyldimethylsilyl)oxy)-4-(4-fluoro-N-methylphenylsulfonamido)-2-methylbutyl)-2-fluoro-N-((2S)-1-((4-methoxybenzyl)oxy)propan-2-yl)-5-nitrobenzenesulfonamide
• Synonyms: N-((2R,3R)-3-((tert-butyldimethylsilyl)oxy)-4-(4-fluoro-N-methylphenylsulfonamido)-2-methylbutyl)-2-fluoro-N-((2S)-1-((4-methoxybenzyl)oxy)propan-2-yl)-5-nitrobenzenesulfonamide
• CAS NO: 1403480-28-3
• Molecular Weight: 786.003
• Mol File: 1403480-28-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: N-((2R,3R)-3-((tert-butyldimethylsilyl)oxy)-4-(4-fluoro-N-methylphenylsulfonamido)-2-methylbutyl)-2-fluoro-N-((2S)-1-((4-methoxybenzyl)oxy)propan-2-yl)-5-nitrobenzenesulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-((2R,3R)-3-((tert-butyldimethylsilyl)oxy)-4-(4-fluoro-N-methylphenylsulfonamido)-2-methylbutyl)-2-fluoro-N-((2S)-1-((4-methoxybenzyl)oxy)propan-2-yl)-5-nitrobenzenesulfonamide(1403480-28-3)
• EPA Substance Registry System: N-((2R,3R)-3-((tert-butyldimethylsilyl)oxy)-4-(4-fluoro-N-methylphenylsulfonamido)-2-methylbutyl)-2-fluoro-N-((2S)-1-((4-methoxybenzyl)oxy)propan-2-yl)-5-nitrobenzenesulfonamide(1403480-28-3)

Safety Data

• Hazardous Substances Data: 1403480-28-3(Hazardous Substances Data)

Upstream product

• 1403480-06-7 (2S,3R)-3-(((tert-butyldimethylsilyl)oxy)-4-(4-fluoro-N-methylphenylsulfonamido)-N-(2S)-1-((4-methoxybenzyl)oxy)propan-2-yl)-2-methylbutanamide 
• 1255212-77-1 tert-butyl ((2R,3S)-2-((tert-butyldimethylsilyl)oxy)-4-(((2S)-1-((4-methoxybenzyl)oxy)propan-2-yl)amino)-3-methyl-4-oxobutyl)(methyl)carbamate 
• 1403480-07-8 N-((2R,3R)-2-((tert-butyldimethylsilyl)oxy)-4-(((2S)-1-((4-methoxybenzyl)oxy)propan-2-yl)amino)-3-methylbutyl)-4-fluoro-N-methylbenzenesulfonamide 
• 713-21-3 2-fluoro-5-nitrobenzene-1-sulfonyl chloride 
• 349-88-2 4-Fluorobenzenesulfonyl chloride 

Downstream Products

• 1403480-44-3 2-(but-3-en-1-yloxy)-N-((2R,3R)-3-((tert-butyldimethylsilyl)oxy)-4-(4-fluoro-Nmethylphenylsulfonamido)-2-methylbutyl)-N-((2S)-1-((4-methoxybenzyl)oxy)propan-2-yl)-5-nitrobenzenesulfonamide 
• 1403480-61-4 2-(but-3-en-1-yloxy)-N-((2R,3R)-4-(4-fluoro-N-methylphenylsulfonamido)-3-hydroxy-2-methylbutyl)-N-((2S)-1-((4-methoxybenzyl)oxy)propan-2-yl)-5-nitrobenzenesulfonamide 
• 1403480-81-8 N-((2R,3R)-3-(allyloxy)-4-(4-fluoro-N-methylphenylsulfonamido)-2-methylbutyl)-2-(but-3-en-1-yloxy)-N-((2S)-1-((4-methoxybenzyl)oxy)propan-2-yl)-5-nitrobenzenesulfonamide 
• 1403481-44-6 15-amino-4-fluoro-N-(((4R,5R)-2-((S)-1-((4-methoxybenzyl)oxy)propan-2-yl)-4-methyl-1,1-dioxido-3,4,5,7,8,9,10,11-octahydro-2H-benzo[b][1,9,4,5]dioxathiaazacyclotetradecin-5-yl)methyl)-N-methylbenzenesulfonamide 

Relevant articles and documents

Diversity-oriented synthesis-facilitated medicinal chemistry: Toward the development of novel antimalarial agents

Here, we describe medicinal chemistry that was accelerated by a diversity-oriented synthesis (DOS) pathway, and in vivo studies of our previously reported macrocyclic antimalarial agent that derived from the synthetic pathway. Structure-activity relationships that focused on both appendage and skeletal features yielded a nanomolar inhibitor of P. falciparum asexual blood-stage growth with improved solubility and microsomal stability and reduced hERG binding. The build/couple/pair (B/C/P) synthetic strategy, used in the preparation of the original screening library, facilitated medicinal chemistry optimization of the antimalarial lead.