1411986-20-3

Basic information

• Product Name: C₂₁H₂₅NO₃
• Synonyms: C₂₁H₂₅NO₃
• CAS NO: 1411986-20-3
• Molecular Weight: 339.434
• Mol File: 1411986-20-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₁H₂₅NO₃(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₁H₂₅NO₃(1411986-20-3)
• EPA Substance Registry System: C₂₁H₂₅NO₃(1411986-20-3)

Safety Data

• Hazardous Substances Data: 1411986-20-3(Hazardous Substances Data)

Upstream product

• 62-53-3 aniline 
• 6654-36-0 methyl 6-oxohexanoate 
• 4547-43-7 methyl 6-hydroxycaproate 
• 502-44-3 hexahydro-2H-oxepin-2-one 
• 1411986-02-1 methyl 6-phenyl-8-oxo-8-(phenylamino)octanoate 

Relevant articles and documents

The structural requirements of histone deacetylase inhibitors: Suberoylanilide hydroxamic acid analogs modified at the C6 position

Suberoylanilide hydroxamic acid (SAHA, Vorinostat), the first FDA-approved histone deacetylase (HDAC) inhibitor drug, was modified at the C6 position to study the structural requirements for high potency and selectivity. Substituents on the C6 position only modestly influenced inhibitor potency, with poorer activity observed as substituent size increased. Interestingly, C6 substituents also modestly influenced selectivity compared to the parent compound, SAHA. This systematic study documenting the influence of substituents on the SAHA linker region will aid development of anti-cancer drugs targeting HDAC proteins.