141300-55-2 Usage
General Description
1,25-dihydroxy-21-norvitamin D3, also known as 1,25-(OH)2-21-norvitamin D3, is a synthetic vitamin D analog that has been developed as a potential treatment for various diseases. It is a potent agonist for the vitamin D receptor and has demonstrated anti-proliferative and pro-differentiating effects in cancer cells. Additionally, 1,25-dihydroxy-21-norvitamin D3 has been shown to regulate calcium and phosphorus metabolism, as well as exert immunomodulatory and anti-inflammatory effects. Research on this compound is ongoing, with the potential for further therapeutic applications in the future.
Check Digit Verification of cas no
The CAS Registry Mumber 141300-55-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,1,3,0 and 0 respectively; the second part has 2 digits, 5 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 141300-55:
(8*1)+(7*4)+(6*1)+(5*3)+(4*0)+(3*0)+(2*5)+(1*5)=72
72 % 10 = 2
So 141300-55-2 is a valid CAS Registry Number.
InChI:InChI=1/C26H42O3/c1-18-19(16-22(27)17-23(18)28)10-11-20-9-7-14-25(4)21(12-15-26(20,25)5)8-6-13-24(2,3)29/h10-11,21-23,27-29H,1,6-9,12-17H2,2-5H3/b19-10-,20-11+/t21-,22+,23-,25+,26-/m0/s1
141300-55-2Relevant articles and documents
Synthetic studies of Vitamin D analogues. X. Synthesis and biological activities of 1α,25-dihydroxy-21-norvitamin D3
Kubodera,Miyamoto,Matsumoto,Kawanishi,Ohkawa,Mori
, p. 648 - 651 (2007/10/02)
1α,25-Dihydroxy-21-norvitamin D3 (3) was synthesized from 1α-hydroxydehydroepiandrosterone (4). Certain biological properties of 3 were examined in comparison with those of 1α,25-dihydroxy vitamin D3 (1) and 1α,25-dihydroxy-21-nor-20-oxavitamin D3 (2) to evaluate the effect of the 21-methyl substituent on biological activities. The differentiation-inducing activity of 3 towards human myeloid leukemia cells was approximately one-fifth of that of 1, while in the binding affinity with chick intestinal cytosolic receptor, 3 was about one-tenth of that of 1. The rather weak effect of 3 on serum calcium levels in normal mice at a dosage of 500 μg/kg (intravenous administration) indicates that the essential importance of the 21-methyl moiety may lie in its effect on the regulation of calcium metabolism.
