141300-65-4

Basic information

• Product Name: 1α,3β,25-trihydroxy-21-norcholesta-5,7-diene
• Synonyms: 1α,3β,25-trihydroxy-21-norcholesta-5,7-diene
• CAS NO: 141300-65-4
• Molecular Weight: 402.618
• Mol File: 141300-65-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1α,3β,25-trihydroxy-21-norcholesta-5,7-diene(CAS DataBase Reference)
• NIST Chemistry Reference: 1α,3β,25-trihydroxy-21-norcholesta-5,7-diene(141300-65-4)
• EPA Substance Registry System: 1α,3β,25-trihydroxy-21-norcholesta-5,7-diene(141300-65-4)

Safety Data

• Hazardous Substances Data: 141300-65-4(Hazardous Substances Data)

Upstream product

• 20998-18-9 1α,3β-dihydroxy-androst-5-en-17-one 

Downstream Products

• 141300-55-2 1alpha,25-Dihydroxy-21-norvitamin D₃ 

Relevant articles and documents

Synthetic studies of Vitamin D analogues. X. Synthesis and biological activities of 1α,25-dihydroxy-21-norvitamin D3

1α,25-Dihydroxy-21-norvitamin D3 (3) was synthesized from 1α-hydroxydehydroepiandrosterone (4). Certain biological properties of 3 were examined in comparison with those of 1α,25-dihydroxy vitamin D3 (1) and 1α,25-dihydroxy-21-nor-20-oxavitamin D3 (2) to evaluate the effect of the 21-methyl substituent on biological activities. The differentiation-inducing activity of 3 towards human myeloid leukemia cells was approximately one-fifth of that of 1, while in the binding affinity with chick intestinal cytosolic receptor, 3 was about one-tenth of that of 1. The rather weak effect of 3 on serum calcium levels in normal mice at a dosage of 500 μg/kg (intravenous administration) indicates that the essential importance of the 21-methyl moiety may lie in its effect on the regulation of calcium metabolism.